Short Communications Incorporating Mouse Genome Mammalian Genome 12, 664–667 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s003350020036 The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus Marielena V. McGuire, Pharnuk Suthipinijtham, Nicholas R.J. Gascoigne Department of Immunology, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA Received: 12 December 2000 / Accepted: 6 April 2001 Chromatin remodeling complexes are important factors in the sion at promoters lacking DNA-bound trans-activators (Malone et regulation of RNA transcription, DNA replication, recombination, al. 1991). DUF is involved in DNA replication through unwinding and repair. Two major types of chromatin remodeling enzymes of duplex DNA (Okuhara et al. 1999). appear to be highly conserved: the ATP-dependent remodeling T cell development in the thymus requires the coordinated complexes and nuclear histone acetyltransferases (HATs) and expression of thymus-specific and ubiquitously expressed genes deacetylases (HDACs). Recently another chromatin remodeling and recombination of T cell receptor (TCR) genes, all of which complex, “facilitates chromatin transcription” (FACT), was iso- require chromatin remodeling (Kim et al. 1999; Cherry and Bal- lated and described as a complex that can facilitate RNA
Mammalian Genome – Springer Journals
Published: Feb 18, 2014
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