Mammalian Genome 10, 1032–1035 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts 1, 2 3 3 1,3 Sidong Huang, * Jeremiah M. Scharf, Joseph D. Growney, Matthew G. Endrizzi, William F. Dietrich Howard Hughes Medical Institute, Boston, MA USA Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA Harvard Medical School, Department of Genetics, 200 Longwood Avenue, Boston, Massachusetts 02115, USA Received: 29 March 1999 / Accepted: 10 June 1999 The region of distal mouse Chromosome (Chr) 13 in the vicinity of existence of only one complete human NAIP cDNA sequence, it the Lgn1 locus harbors a number of interesting biological features. has been speculated that only one functional NAIP gene exists in First, it contains allelic variation in an as yet unidentified gene the human genome (Roy et al. 1995). In contrast, the mouse has (Lgn1) that determines whether mouse macrophages are permis- several (perhaps six or more) closely linked Naip genomic loci, all sive or non-permissive for the intracellular replication of the Le- of which map to a single gene cluster within the Lgn1/Sma interval gionnaire’s disease bacterium, Legionella pneumophila (Dietrich
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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