Access the full text.
Sign up today, get DeepDyve free for 14 days.
IA Macdonald, JF Jellett, DE Mahony (1979)
12Alpha-hydroxysteroid dehydrogenase from Clostridium group P strain C48-50 ATCC No. 29733: partial purification and characterizationJ Lipid Res, 20
M Makishima, AY Okamoto, JJ Repa, H Tu, RM Learned, A Luk, MV Hull, KD Lustig, DJ Mangelsdorf, B Shan (1999)
Identification of a nuclear receptor for bile acidsScience, 284
W Cui, ZY Jiang, Q Cai, RY Zhang, WZ Wu, JC Wang, J Fei, SD Zhang, TQ Han (2010)
Decreased NPC1L1 expression in the liver from Chinese female gallstone patientsLipids Health Dis, 9
T Gerloff, B Stieger, B Hagenbuch, J Madon, L Landmann, J Roth, AF Hofmann, PJ Meier (1998)
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liverJ Biol Chem, 273
BV Jones, M Begley, C Hill, CG Gahan, JR Marchesi (2008)
Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiomeProc Natl Acad Sci USA, 105
HA Pitt, MA Lewinski, EL Muller, V Porter-Fink, L DenBesten (1984)
Ileal resection-induced gallstones: altered bilirubin or cholesterol metabolism?Surgery, 96
DK Lee, PI Tarr, WG Haigh, SP Lee (1999)
Bacterial DNA in mixed cholesterol gallstonesAm J Gastroenterol, 94
JS Matsumura, MA Greiner, DL Nahrwold, LG Dawes (1993)
Reduced ileal taurocholate absorption with total parenteral nutritionJ Surg Res, 54
J Heider (2001)
A new family of CoA-transferasesFEBS Lett, 509
CM Franz, I Specht, P Haberer, WH Holzapfel (2001)
Bile salt hydrolase activity of Enterococci isolated from food: screening and quantitative determinationJ Food Prot, 64
W Kratzer, RA Mason, V Kachele (1999)
Prevalence of gallstones in sonographic surveys worldwideJ Clin Ultrasound, 27
A Chawla, WA Boisvert, CH Lee, BA Laffitte, Y Barak, SB Joseph, D Liao, L Nagy, PA Edwards, LK Curtiss, RM Evans, P Tontonoz (2001)
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesisMol Cell, 7
R Edenharder, M Pfutzner, R Hammann (1989)
NADP-dependent 3 beta-, 7 alpha- and 7 beta-hydroxysteroid dehydrogenase activities from a lecithinase-lipase-negative Clostridium species 25.11.cBiochim Biophys Acta, 1002
J Staudinger, Y Liu, A Madan, S Habeebu, CD Klaassen (2001)
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptorDrug Metab Dispos, 29
D Debray, D Rainteau, V Barbu, M Rouahi, MH El, S Lerondel, C Rey, L Humbert, D Wendum, CH Cottart, P Dawson, N Chignard, C Housset (2012)
Defects in gallbladder emptying and bile acid homeostasis in mice with cystic fibrosis transmembrane conductance regulator deficienciesGastroenterology, 142
B Desvergne, W Wahli (1999)
Peroxisome proliferator-activated receptors: nuclear control of metabolismEndocr Rev, 20
T Inagaki, M Choi, A Moschetta, L Peng, CL Cummins, JG McDonald, G Luo, SA Jones, B Goodwin, JA Richardson, RD Gerard, JJ Repa, DJ Mangelsdorf, SA Kliewer (2005)
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasisCell Metab, 2
M Norlin, U Andersson, I Bjorkhem, K Wikvall (2000)
Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A)J Biol Chem, 275
BL Shneider (2001)
Intestinal bile acid transport: biology, physiology, and pathophysiologyJ Pediatr Gastroenterol Nutr, 32
L Dethlefsen, M McFall-Ngai, DA Relman (2007)
An ecological and evolutionary perspective on human–microbe mutualism and diseaseNature, 449
GA Kullak-Ublick, B Stieger, PJ Meier (2004)
Enterohepatic bile salt transporters in normal physiology and liver diseaseGastroenterology, 126
DJ Peet, SD Turley, W Ma, BA Janowski, JM Lobaccaro, RE Hammer, DJ Mangelsdorf (1998)
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alphaCell, 93
H Tanaka, K Doesburg, T Iwasaki, I Mierau (1999)
Screening of lactic acid bacteria for bile salt hydrolase activityJ Dairy Sci, 82
L Stewart, JM Griffiss, GA Jarvis, LW Way (2007)
Gallstones containing bacteria are biofilms: bacterial slime production and ability to form pigment solids determines infection severity and bacteremiaJ Gastrointest Surg, 11
JJ Cali, DW Russell (1991)
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesisJ Biol Chem, 266
LA Thomas, MJ Veysey, GM Murphy, D Russell-Jones, GL French, JA Wass, RH Dowling (2005)
Octreotide induced prolongation of colonic transit increases faecal anaerobic bacteria, bile acid metabolising enzymes, and serum deoxycholic acid in patients with acromegalyGut, 54
B Hagenbuch, PJ Meier (2004)
Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional propertiesPflug Arch, 447
JM Dietschy, SD Turley (2002)
Control of cholesterol turnover in the mouseJ Biol Chem, 277
L Stewart, JM Griffiss, JA Jarvis, LW Way (2007)
Bacteria entombed in the center of cholesterol gallstones induce fewer infectious manifestations than bacteria in the matrix of pigment stonesJ Gastrointest Surg, 11
J Zubler, G Markowski, S Yale, R Graham, TC Rosenthal (1998)
Natural history of asymptomatic gallstones in family practice office practicesArch Fam Med, 7
IA MacDonald, JF Jellett, DE Mahony, LV Holdeman (1979)
Bile salt 3 alpha- and 12 alpha-hydroxysteroid dehydrogenases from Eubacterium lentum and related organismsAppl Environ Microbiol, 37
AJ Rose, DM Berriel, A Reimann, J Klement, T Walcher, A Krones-Herzig, O Strobel, J Werner, A Peters, A Kleyman, JP Tuckermann, A Vegiopoulos, S Herzig (2011)
Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptorCell Metab, 14
HQ Ye, DH Mallonee, JE Wells, I Bjorkhem, PB Hylemon (1999)
The bile acid-inducible baiF gene from Eubacterium sp. Strain VPI 12708 encodes a bile acid-coenzyme a hydrolaseJ Lipid Res, 40
L Liu, A Aigner, RD Schmid (2011)
Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciensAppl Microbiol Biotechnol, 90
O Renner, S Harsch, E Schaeffeler, S Winter, M Schwab, M Krawczyk, J Rosendahl, H Wittenburg, F Lammert, EF Stange (2009)
A variant of the SLC10A2 gene encoding the apical sodium-dependent bile acid transporter is a risk factor for gallstone diseasePLoS One, 4
KL Kavanagh, H Jornvall, B Persson, U Oppermann (2008)
Medium- and short-chain dehydrogenase/reductase gene and protein families: the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymesCell Mol Life Sci, 65
DH Mallonee, PB Hylemon (1996)
Sequencing and expression of a gene encoding a bile acid transporter from Eubacterium sp. Strain VPI 12708J Bacteriol, 178
NJ Cherrington, DP Hartley, N Li, DR Johnson, CD Klaassen (2002)
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in ratsJ Pharmacol Exp Ther, 300
JD Sutherland, IA Macdonald (1982)
The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonumJ Lipid Res, 23
J Li-Hawkins, EG Lund, AD Bronson, DW Russell (2000)
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterolJ Biol Chem, 275
CJ Soroka, JM Lee, F Azzaroli, JL Boyer (2001)
Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liverHepatology, 33
P Lepercq, P Gerard, F Beguet, P JP, P Grill, P Relan, CP Cayuela, C Juste (2004)
Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by Clostridium baratii isolated from human fecesFEMS Microbiol Lett, 235
JV Sitzmann, HA Pitt, PA Steinborn, ZR Pasha, RC Sanders (1990)
Cholecystokinin prevents parenteral nutrition induced biliary sludge in humansSurg Gynecol Obstet, 170
L Masco, C Crockaert, K Hoorde, J Swings, G Huys (2007)
In vitro assessment of the gastrointestinal transit tolerance of taxonomic reference strains from human origin and probiotic product isolates of BifidobacteriumJ Dairy Sci, 90
R Gopal-Srivastava (1990)
Mallonee DH, White WB, Hylemon PB: Multiple copies of a bile acid-inducible gene in Eubacterium sp. Strain VPI 12708J Bacteriol, 172
PA Dawson, J Haywood, AL Craddock, M Wilson, M Tietjen, K Kluckman, N Maeda, JS Parks (2003)
Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in miceJ Biol Chem, 278
A Henkel, Z Wei, DE Cohen, RM Green (2005)
Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstonesMamm Genome, 16
LA Thomas, A King, GL French, GM Murphy, RH Dowling (1997)
Cholylglycine hydrolase and 7alpha-dehydroxylase optimum assay conditions in vitro and caecal enzyme activities ex vivoClin Chim Acta, 268
O Muller, C Schalla, J Scheibner, EF Stange, M Fuchs (2002)
Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant miceBiochem J, 361
L Yu, RE Hammer, J Li-Hawkins, K Bergmann, D Lutjohann, JC Cohen, HH Hobbs (2002)
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretionProc Natl Acad Sci USA, 99
D Jung, AC Fantin, U Scheurer, M Fried, GA Kullak-Ublick (2004)
Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptorGut, 53
F Hoffmann, E Maser (2007)
Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamilyDrug Metab Rev, 39
GB Kim, BH Lee (2008)
Genetic analysis of a bile salt hydrolase in Bifidobacterium animalis subsp. Lactis KL612J Appl Microbiol, 105
X Xia, D Jung, P Webb, A Zhang, B Zhang, L Li, SD Ayers, C Gabbi, Y Ueno, JA Gustafsson, G Alpini, DD Moore, GD Lesage (2012)
Liver X receptor beta and peroxisome proliferator-activated receptor delta regulate cholesterol transport in murine cholangiocytesHepatology, 56
H Xiong, K Yoshinari, KL Brouwer, M Negishi (2002)
Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbitalDrug Metab Dispos, 30
RL Gebhard, WF Prigge, HJ Ansel, L Schlasner, SR Ketover, D Sande, K Holtmeier, FJ Peterson (1996)
The role of gallbladder emptying in gallstone formation during diet-induced rapid weight lossHepatology, 24
KM Giacomini, SM Huang, DJ Tweedie, LZ Benet, KL Brouwer, X Chu, A Dahlin, R Evers, V Fischer, KM Hillgren, KA Hoffmaster, T Ishikawa, D Keppler, RB Kim, CA Lee, M Niemi, JW Polli, Y Sugiyama, PW Swaan, JA Ware, SH Wright, SW Yee, MJ Zamek-Gliszczynski, L Zhang (2010)
Membrane transporters in drug developmentNat Rev Drug Discov, 9
GA Kullak-Ublick, B Hagenbuch, B Stieger, AW Wolkoff, PJ Meier (1994)
Functional characterization of the basolateral rat liver organic anion transporting polypeptideHepatology, 20
JD Sutherland, CN Williams, DM Hutchison, LV Holdeman (1987)
Oxidation of primary bile acids by a 7 alpha-hydroxysteroid dehydrogenase elaborating Clostridium bifermentans soil isolateCan J Microbiol, 33
PA Dawson, T Lan, A Rao (2009)
Bile acid transportersJ Lipid Res, 50
C Abadie, M Hug, C Kubli, N Gains (1994)
Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faecesBiochem J, 299
P Tontonoz, DJ Mangelsdorf (2003)
Liver X receptor signaling pathways in cardiovascular diseaseMol Endocrinol, 17
AK Groen, VW Bloks, RH Bandsma, R Ottenhoff, G Chimini, F Kuipers (2001)
Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDLJ Clin Invest, 108
IA MacDonald, DE Mahony, JF Jellet, CE Meier (1977)
NAD-dependent 3alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Eubacterium lentum ATCC no. 25559Biochim Biophys Acta, 489
S Dueland, JD Trawick, MS Nenseter, AA MacPhee, RA Davis (1992)
Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low density lipoprotein receptor to cholesterol repressionJ Biol Chem, 267
D Jung, M Fried, GA Kullak-Ublick (2002)
Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alphaJ Biol Chem, 277
M Acalovschi, S Tirziu, E Chiorean, M Krawczyk, F Grunhage, F Lammert (2009)
Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controlsLipids, 44
H Wittenburg, MA Lyons, R Li, GA Churchill, MC Carey, B Paigen (2003)
FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in miceGastroenterology, 125
AW Wolkoff, DE Cohen (2003)
Bile acid regulation of hepatic physiology: I. Hepatocyte transport of bile acidsAm J Physiol Gastrointest Liver Physiol, 284
M Trauner, JL Boyer (2003)
Bile salt transporters: molecular characterization, function, and regulationPhysiol Rev, 83
JL Staudinger, B Goodwin, SA Jones, D Hawkins-Brown, KI MacKenzie, A LaTour, Y Liu, CD Klaassen, KK Brown, J Reinhard, TM Willson, BH Koller, SA Kliewer (2001)
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicityProc Natl Acad Sci USA, 98
JP Coleman, WB White, M Lijewski, PB Hylemon (1988)
Nucleotide sequence and regulation of a gene involved in bile acid 7-dehydroxylation by Eubacterium sp. Strain VPI 12708J Bacteriol, 170
SG Lo, M Petruzzelli, A Moschetta (2008)
A translational view on the biliary lipid secretory networkBiochim Biophys Acta, 1781
JM Ridlon, DJ Kang, PB Hylemon (2006)
Bile salt biotransformations by human intestinal bacteriaJ Lipid Res, 47
V Aries, MJ Hill (1970)
Degradation of steroids by intestinal bacteria. II. Enzymes catalysing the oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in cholic acid, and the dehydroxylation of the 7-hydroxyl groupBiochim Biophys Acta, 202
C Yu, F Wang, M Kan, C Jin, RB Jones, M Weinstein, CX Deng, WL McKeehan (2000)
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4J Biol Chem, 275
Y Honjo, S Sasaki, Y Kobayashi, H Misawa, H Nakamura (2006)
1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptorJ Endocrinol, 188
V Prabha, M Gupta (1989)
Gupta KG: Kinetic properties of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli 080Can J Microbiol, 35
EJ Gibney (1990)
Asymptomatic gallstonesBr J Surg, 77
J He, S Nishida, M Xu, M Makishima, W Xie (2011)
PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile saltsGastroenterology, 140
KJ Erpecum, NG Venneman, P Portincasa, GP Vanberge-Henegouwen (2000)
Review article: agents affecting gall-bladder motility–role in treatment and prevention of gallstonesAliment Pharmacol Ther, 14
JY Chiang (2004)
Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanismsJ Hepatol, 40
A Srivastava, A Srivastava, N Srivastava, G Choudhuri, B Mittal (2011)
Organic anion transporter 1B1 (SLCO1B1) polymorphism and gallstone formation: high incidence of Exon4 CA genotype in female patients in North IndiaHepatol Res, 41
JJ Repa, KE Berge, C Pomajzl, JA Richardson, H Hobbs, DJ Mangelsdorf (2002)
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and betaJ Biol Chem, 277
GW Tannock, MP Dashkevicz, SD Feighner (1989)
Lactobacilli and bile salt hydrolase in the murine intestinal tractAppl Environ Microbiol, 55
S Hirano, N Masuda (1981)
Epimerization of the 7-hydroxy group of bile acids by the combination of two kinds of microorganisms with 7 alpha- and 7 beta-hydroxysteroid dehydrogenase activity, respectivelyJ Lipid Res, 22
R Edenharder, J Schneider (1985)
12 beta-dehydrogenation of bile acids by Clostridium paraputrificum, C. Tertium, and C. Difficile and epimerization at carbon-12 of deoxycholic acid by cocultivation with 12 alpha-dehydrogenating Eubacterium lentumAppl Environ Microbiol, 49
AF Hofmann (2007)
Biliary secretion and excretion in health and disease: current conceptsAnn Hepatol, 6
M Niemi, MK Pasanen, PJ Neuvonen (2011)
Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptakePharmacol Rev, 63
K Hirata, MH Nathanson (2001)
Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liverGastroenterology, 121
C Jungst, N Sreejayan, MI Eder, N Stillfried, B Zundt, FW Spelsberg, GA Kullak-Ublick, D Jungst, C Ritter (2007)
Lipid peroxidation and mucin secretagogue activity in bile of gallstone patientsEur J Clin Invest, 37
A Moschetta, AL Bookout, DJ Mangelsdorf (2004)
Prevention of cholesterol gallstone disease by FXR agonists in a mouse modelNat Med, 10
U Beuers, U Spengler, W Kruis, U Aydemir, B Wiebecke, W Heldwein, M Weinzierl, GR Pape, T Sauerbruch, G Paumgartner (1992)
Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo-controlled trialHepatology, 16
IA Macdonald, DM Hutchison, TP Forrest, VD Bokkenheuser, J Winter, LV Holdeman (1983)
Metabolism of primary bile acids by Clostridium perfringensJ Steroid Biochem, 18
I Bergheim, S Harsch, O Mueller, S Schimmel, P Fritz, EF Stange (2006)
Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriersJ Lipid Res, 47
JJ Fremont-Rahl, Z Ge, C Umana, MT Whary, NS Taylor, S Muthupalani, MC Carey, JG Fox, KJ Maurer (2013)
An analysis of the role of the indigenous microbiota in cholesterol gallstone pathogenesisPLoS One, 8
JE Wells, PB Hylemon (2000)
Identification and characterization of a bile acid 7alpha-dehydroxylation operon in Clostridium sp. Strain TO-931, a highly active 7alpha-dehydroxylating strain isolated from human fecesAppl Environ Microbiol, 66
B Hagenbuch, PJ Meier (1994)
Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporterJ Clin Invest, 93
TA Kerr, S Saeki, M Schneider, K Schaefer, S Berdy, T Redder, B Shan, DW Russell, M Schwarz (2002)
Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesisDev Cell, 2
EB Neufeld, SJ Demosky, JA Stonik, C Combs, AT Remaley, N Duverger, S Santamarina-Fojo, HJ Brewer (2002)
The ABCA1 transporter functions on the basolateral surface of hepatocytesBiochem Biophys Res Commun, 297
T Iida, S Nishida, FC Chang, T Niwa, J Goto, T Nambara (1993)
Potential bile acid metabolites. 19. The epimeric 3 alpha,6,7 beta-trihydroxy- and 3 alpha,6,7 beta,12 alpha-tetrahydroxy-5 alpha-cholanoic acidsSteroids, 58
EJ Stellwag, PB Hylemon (1976)
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilisBiochim Biophys Acta, 452
B Goodwin, SA Jones, RR Price, MA Watson, DD McKee, LB Moore, C Galardi, JG Wilson, MC Lewis, ME Roth, PR Maloney, TM Willson, SA Kliewer (2000)
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesisMol Cell, 6
CA Elkins, DC Savage (2003)
CbsT2 from Lactobacillus johnsonii 100–100 is a transport protein of the major facilitator superfamily that facilitates bile acid antiportJ Mol Microbiol Biotechnol, 6
GB Kim, CM Miyamoto, EA Meighen, BH Lee (2004)
Cloning and characterization of the bile salt hydrolase genes (bsh) from Bifidobacterium bifidum strainsAppl Environ Microbiol, 70
T Claudel, G Zollner, M Wagner, M Trauner (2011)
Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone diseaseBiochim Biophys Acta, 1812
R Edenharder, A Pfutzner, R Hammann (1989)
Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productusBiochim Biophys Acta, 1004
B Sun, C Kantzow, S Bresch, K Castiglione, D Weuster-Botz (2013)
Multi-enzymatic one-pot reduction of dehydrocholic acid to 12-keto-ursodeoxycholic acid with whole-cell biocatalystsBiotechnol Bioeng, 110
M Begley, RD Sleator, CG Gahan, C Hill (2005)
Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenesInfect Immun, 73
MD Krasowski, EJ Reschly, S Ekins (2008)
Intrinsic disorder in nuclear hormone receptorsJ Proteome Res, 7
H Tanaka, H Hashiba, J Kok, I Mierau (2000)
Bile salt hydrolase of Bifidobacterium longum-biochemical and genetic characterizationAppl Environ Microbiol, 66
S Buch, C Schafmayer, H Volzke, C Becker, A Franke, H Eller-Eberstein, C Kluck, I Bassmann, M Brosch, F Lammert, JF Miquel, F Nervi, M Wittig, D Rosskopf, B Timm, C Holl, M Seeger, A ElSharawy, T Lu, J Egberts, F Fandrich, UR Folsch, M Krawczak, S Schreiber, P Nurnberg, J Tepel, J Hampe (2007)
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone diseaseNat Genet, 39
Z Araya, K Wikvall (1999)
6Alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomesBiochim Biophys Acta, 1438
MD Krasowski, A Ni, LR Hagey, S Ekins (2011)
Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARMol Cell Endocrinol, 334
TC McCarthy, X Li, CJ Sinal (2005)
Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acidsJ Biol Chem, 280
AT Nies, M Schwab, D Keppler (2008)
Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugsExpert Opin Drug Metab Toxicol, 4
O Rosmorduc, B Hermelin, PY Boelle, R Parc, J Taboury, R Poupon (2003)
ABCB4 gene mutation-associated cholelithiasis in adultsGastroenterology, 125
JP Coleman, LL Hudson, MJ Adams (1994)
Characterization and regulation of the NADP-linked 7 alpha-hydroxysteroid dehydrogenase gene from Clostridium sordelliiJ Bacteriol, 176
A Lanzini, F Lanzarotto (2000)
Review article: the ‘mechanical pumps’ and the enterohepatic circulation of bile acids—defects in coeliac diseaseAliment Pharmacol Ther, 14
DH Mallonee, MA Lijewski, PB Hylemon (1995)
Expression in Escherichia coli and characterization of a bile acid-inducible 3 alpha-hydroxysteroid dehydrogenase from Eubacterium sp. Strain VPI 12708Curr Microbiol, 30
JD Mulligan, MT Flowers, A Tebon, JJ Bitgood, C Wellington, MR Hayden, AD Attie (2003)
ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickensJ Biol Chem, 278
JN Harris, PB Hylemon (1978)
Partial purification and characterization of NADP-dependent 12alpha-hydroxysteroid dehydrogenase from Clostridium leptumBiochim Biophys Acta, 528
GB Kim, SH Yi, BH Lee (2004)
Purification and characterization of three different types of bile salt hydrolases from Bifidobacterium strainsJ Dairy Sci, 87
BA Skalhegg (1975)
3Alpha-hydroxysteroid dehydrogenase from Pseudomonas testosteroni: Kinetic properties with NAD and its thionicotinamide analogueEur J Biochem, 50
O Dussurget, D Cabanes, P Dehoux, M Lecuit, C Buchrieser, P Glaser, P Cossart (2002)
Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosisMol Microbiol, 45
LA Thomas, MJ Veysey, T Bathgate, A King, G French, NC Smeeton, GM Murphy, RH Dowling (2000)
Mechanism for the transit-induced increase in colonic deoxycholic acid formation in cholesterol cholelithiasisGastroenterology, 119
T Akao, T Akao, K Kobashi (1987)
Purification and characterization of 7 beta-hydroxysteroid dehydrogenase from Ruminococcus sp. of human intestineJ Biochem, 102
MJ Bennett, SL McKnight, JP Coleman (2003)
Cloning and characterization of the NAD-dependent 7alpha-Hydroxysteroid dehydrogenase from Bacteroides fragilisCurr Microbiol, 47
HR Kast, B Goodwin, PT Tarr, SA Jones, AM Anisfeld, CM Stoltz, P Tontonoz, S Kliewer, TM Willson, PA Edwards (2002)
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptorJ Biol Chem, 277
G Zollner, HU Marschall, M Wagner, M Trauner (2006)
Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerationsMol Pharm, 3
FY Lee, H Lee, ML Hubbert, PA Edwards, Y Zhang (2006)
FXR, a multipurpose nuclear receptorTrends Biochem Sci, 31
CA Elkins, SA Moser, DC Savage (2001)
Genes encoding bile salt hydrolases and conjugated bile salt transporters in Lactobacillus johnsonii 100–100 and other Lactobacillus speciesMicrobiology, 147
R Edenharder, A Pfutzner (1988)
Characterization of NADP-dependent 12 beta-hydroxysteroid dehydrogenase from Clostridium paraputrificumBiochim Biophys Acta, 962
PB Hylemon, JA Sherrod (1975)
Multiple forms of 7-alpha-hydroxysteroid dehydrogenase in selected strains of Bacteroides fragilisJ Bacteriol, 122
C Brendel, K Schoonjans, OA Botrugno, E Treuter, J Auwerx (2002)
The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activityMol Endocrinol, 16
KN Lazaridis, L Pham, P Tietz, RA Marinelli, PC DeGroen, S Levine, PA Dawson, NF LaRusso (1997)
Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporterJ Clin Invest, 100
RS Sandler, JE Everhart, M Donowitz, E Adams, K Cronin, C Goodman, E Gemmen, S Shah, A Avdic, R Rubin (2002)
The burden of selected digestive diseases in the United StatesGastroenterology, 122
PA Bron, D Molenaar, WM Vos, M Kleerebezem (2006)
DNA micro-array-based identification of bile-responsive genes in Lactobacillus plantarumJ Appl Microbiol, 100
AK Batta, G Salen, R Arora, S Shefer, M Batta, A Person (1990)
Side chain conjugation prevents bacterial 7-dehydroxylation of bile acidsJ Biol Chem, 265
YP Rao, EJ Studer, RT Stravitz, S Gupta, L Qiao, P Dent, PB Hylemon (2002)
Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytesHepatology, 35
O Renner, S Harsch, A Strohmeyer, S Schimmel, EF Stange (2008)
Reduced ileal expression of OSTalpha–OSTbeta in non-obese gallstone diseaseJ Lipid Res, 49
JA Sherrod, PB Hylemon (1977)
Partial purification and characterization of NAD-dependent 7alpha-hydroxysteroid dehydrogenase from Bacteroides thetaiotaomicronBiochim Biophys Acta, 486
M Rossocha, R Schultz-Heienbrok, H Moeller, JP Coleman, W Saenger (2005)
Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl productBiochemistry, 44
DQ Wang, F Schmitz, AS Kopin, MC Carey (2004)
Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasisJ Clin Invest, 114
KJ Maurer, MM Ihrig, AB Rogers, V Ng, G Bouchard, MR Leonard, MC Carey, JG Fox (2005)
Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formationGastroenterology, 128
S Zucoloto, G Muccilo, NA Wright, MR Alison (1985)
Chronic effects of alcohol on the epithelium of the small intestine using two experimental modelsVirchows Arch B, 49
JA Dawson, DH Mallonee, I Bjorkhem, PB Hylemon (1996)
Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. Strain VPI 12708 in Escherichia coliJ Lipid Res, 37
F Berr, GA Kullak-Ublick, G Paumgartner, W Munzing, PB Hylemon (1996)
7 alpha-dehydroxylating bacteria enhance deoxycholic acid input and cholesterol saturation of bile in patients with gallstonesGastroenterology, 111
T Ohama, K Hirano, Z Zhang, R Aoki, K Tsujii, Y Nakagawa-Toyama, K Tsukamoto, C Ikegami, A Matsuyama, M Ishigami, N Sakai, H Hiraoka, K Ueda, S Yamashita, Y Matsuzawa (2002)
Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligandsBiochem Biophys Res Commun, 296
RJ Cano, O McAuliffe, TR Klaenhammer (2005)
Genetic analysis of two bile salt hydrolase activities in Lactobacillus acidophilus NCFMAppl Environ Microbiol, 71
GJ Schroepfer (2000)
Oxysterols: modulators of cholesterol metabolism and other processesPhysiol Rev, 80
B Stieger (2011)
The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formationHandb Exp Pharmacol, 201
T Yoshimoto, H Higashi, A Kanatani, XS Lin, H Nagai, H Oyama, K Kurazono, D Tsuru (1991)
Cloning and sequencing of the 7 alpha-hydroxysteroid dehydrogenase gene from Escherichia coli HB101 and characterization of the expressed enzymeJ Bacteriol, 173
K Kawamoto, I Horibe, K Uchida (1989)
Purification and characterization of a new hydrolase for conjugated bile acids, chenodeoxycholyltaurine hydrolase, from Bacteroides vulgatusJ Biochem, 106
W Xie, A Radominska-Pandya, Y Shi, CM Simon, MC Nelson, ES Ong, DJ Waxman, RM Evans (2001)
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acidsProc Natl Acad Sci USA, 98
G Eggertsen, M Olin, U Andersson, H Ishida, S Kubota, U Hellman, KI Okuda, I Bjorkhem (1996)
Molecular cloning and expression of rabbit sterol 12alpha-hydroxylaseJ Biol Chem, 271
H Uppal, Y Zhai, A Gangopadhyay, S Khadem, S Ren, JA Moser, W Xie (2008)
Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallizationHepatology, 47
H Christiaens, RJ Leer, PH Pouwels, V Verstraete (1992)
Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assayAppl Environ Microbiol, 58
DJ Kang, JM Ridlon, DN Moore, S Barnes, PB Hylemon (2008)
Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductasesBiochim Biophys Acta, 1781
(2004)
Cloning and characterization of the bile salt hydrolase genes (bsh) from Bifidobacteriumbifidum strainsAppl Environ Microbiol, 70
M Schwarz, EG Lund, R Lathe, I Bjorkhem, DW Russell (1997)
Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNAJ Biol Chem, 272
IA Macdonald, EC Meier, DE Mahony, GA Costain (1976)
3Alpha-, 7alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Clostridium perfringensBiochim Biophys Acta, 450
SF Baron, CV Franklund, PB Hylemon (1991)
Cloning, sequencing, and expression of the gene coding for bile acid 7 alpha-hydroxysteroid dehydrogenase from Eubacterium sp. Strain VPI 12708J Bacteriol, 173
T Kok, VW Bloks, H Wolters, R Havinga, PL Jansen, B Staels, F Kuipers (2003)
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in miceBiochem J, 369
DH Mallonee, JL Adams, PB Hylemon (1992)
The bile acid-inducible baiB gene from Eubacterium sp. Strain VPI 12708 encodes a bile acid-coenzyme a ligaseJ Bacteriol, 174
JE Wells, F Berr, LA Thomas, RH Dowling, PB Hylemon (2000)
Isolation and characterization of cholic acid 7alpha-dehydroxylating fecal bacteria from cholesterol gallstone patientsJ Hepatol, 32
IA Macdonald, JD Sutherland (1983)
Further studies on the bile salt induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonumBiochim Biophys Acta, 750
N Tanaka, T Nonaka, T Tanabe, T Yoshimoto, D Tsuru, Y Mitsui (1996)
Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coliBiochemistry-Us, 35
HK Oh, JY Lee, SJ Lim, MJ Kim, GB Kim, JH Kim, SK Hong, DK Kang (2008)
Molecular cloning and characterization of a bile salt hydrolase from Lactobacillus acidophilus PF01J Microbiol Biotechnol, 18
KJ Maurer, VP Rao, Z Ge, AB Rogers, TJ Oura, MC Carey, JG Fox (2007)
T-cell function is critical for murine cholesterol gallstone formationGastroenterology, 133
W Seol, HS Choi, DD Moore (1996)
An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptorsScience, 272
KJ Maurer, AB Rogers, Z Ge, AJ Wiese, MC Carey, JG Fox (2006)
Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective studyAm J Physiol Gastrointest Liver Physiol, 290
IA MacDonald, YP Rochon, DM Hutchison, LV Holdeman (1982)
Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organismsAppl Environ Microbiol, 44
M Wagner, G Zollner, M Trauner (2010)
Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasisSemin Liver Dis, 30
O Kampen, S Buch, M Nothnagel, L Azocar, H Molina, M Brosch, W Erhart, W Schonfels, J Egberts, M Seeger, A Arlt, T Balschun, A Franke, MM Lerch, J Mayerle, W Kratzer, BO Boehm, K Huse, B Schniewind, K Tiemann, ZY Jiang, TQ Han, B Mittal, A Srivastava, M Fenger, T Jorgensen, R Schirin-Sokhan, A Tonjes, H Wittenburg, M Stumvoll, H Kalthoff, F Lammert, J Tepel, K Puschel, T Becker, S Schreiber, M Platzer, H Volzke, M Krawczak, JF Miquel, C Schafmayer, J Hampe (2013)
Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locusHepatology, 57
ZY Jiang, P Parini, G Eggertsen, MA Davis, H Hu, GJ Suo, SD Zhang, LL Rudel, TQ Han, C Einarsson (2008)
Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patientsJ Lipid Res, 49
AF Hofmann (2004)
Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicityDrug Metab Rev, 36
SA Moser, DC Savage (2001)
Bile salt hydrolase activity and resistance to toxicity of conjugated bile salts are unrelated properties in lactobacilliAppl Environ Microbiol, 67
W Kruis, G Forstmaier, C Scheurlen, F Stellaard (1991)
Effect of diets low and high in refined sugars on gut transit, bile acid metabolism, and bacterial fermentationGut, 32
T Maruyama, Y Miyamoto, T Nakamura, Y Tamai, H Okada, E Sugiyama, T Nakamura, H Itadani, K Tanaka (2002)
Identification of membrane-type receptor for bile acids (M-BAR)Biochem Biophys Res Commun, 298
Bile acids entering into enterohepatic circulating are primary acids synthesized from cholesterol in hepatocyte. They are secreted actively across canalicular membrane and carried in bile to gallbladder, where they are concentrated during digestion. About 95 % BAs are actively taken up from the lumen of terminal ileum efficiently, leaving only approximately 5 % (or approximately 0.5 g/d) in colon, and a fraction of bile acids are passively reabsorbed after a series of modifications in the human large intestine including deconjugation and oxidation of hydroxy groups. Bile salts hydrolysis and hydroxy group dehydrogenation reactions are performed by a broad spectrum of intestinal anaerobic bacteria. Next, hepatocyte reabsorbs bile acids from sinusoidal blood, which are carried to liver through portal vein via a series of transporters. Bile acids (BAs) transporters are critical for maintenance of the enterohepatic BAs circulation, where BAs exert their multiple physiological functions including stimulation of bile flow, intestinal absorption of lipophilic nutrients, solubilization, and excretion of cholesterol. Tight regulation of BA transporters via nuclear receptors (NRs) is necessary to maintain proper BA homeostasis. In conclusion, disturbances of enterohepatic circulation may account for pathogenesis of gallstones diseases, including BAs transporters and their regulatory NRs and the metabolism of intestinal bacterias, etc.
The Journal of Membrane Biology – Springer Journals
Published: Aug 9, 2014
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.