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- Publisher
- Springer Journals
- Copyright
- Copyright © 2012 by The Author(s)
- Subject
- Life Sciences; Zoology; Cell Biology; Anatomy
- ISSN
- 0938-8990
- eISSN
- 1432-1777
- DOI
- 10.1007/s00335-012-9422-2
- pmid
- 22968824
- Publisher site
- See Article on Publisher Site
Abstract
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( www.knockoutmouse.org ) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
Journal
Mammalian Genome – Springer Journals
Published: Sep 12, 2012