The Lymph Node in HIV Pathogenesis

The Lymph Node in HIV Pathogenesis Lymph nodes play a central role in the development of adaptive immunity against pathogens and particularly the generation of antigen-specific B cell responses in specialized areas called germinal centers (GCs). Lymph node (LN) pathology was recognized as an important consequence of human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. Investigation into the structural and functional alterations induced by HIV and Simian immunodeficiency virus (SIV) has further cemented the central role that lymphoid tissue plays in HIV/SIV pathogenesis. The coexistence of constant local inflammation, altered tissue architecture, and relative exclusion of virus-specific CD8 T cells from the GCs creates a unique environment for the virus evolution and establishment of viral reservoir in specific GC cells, namely T follicular helper CD4 T cells (Tfh). A better understanding of the biology of immune cells in HIV-infected lymph nodes is a prerequisite to attaining the ultimate goal of complete viral eradication. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current HIV/AIDS Reports Springer Journals

The Lymph Node in HIV Pathogenesis

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Publisher
Springer US
Copyright
Copyright © 2017 by US Government (outside the USA)
Subject
Medicine & Public Health; Medicine/Public Health, general
ISSN
1548-3568
eISSN
1548-3576
D.O.I.
10.1007/s11904-017-0359-7
Publisher site
See Article on Publisher Site

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