Breast Cancer (2018) 25:377–378 https://doi.org/10.1007/s12282-018-0876-2 SPECIAL FEATURE Resistance to hormonal therapy The long and winding road for overcoming resistance to hormone therapy in breast cancer Shigehira Saji Published online: 28 May 2018 © The Japanese Breast Cancer Society 2018 Endocrine therapy is a main modality for hormone receptor useful for stopping the motor driven car, and for avoiding a (HR)-positive breast cancer. In the treatment of advanced restart by engine. Endocrine therapy should be accompanied or metastatic HR-positive breast cancer (ABC/MBC), endo- with it. crine therapy is generally used as sequential therapy, which In this special feature issue of Breast Cancer, three arti- uses a single drug one by one when the disease progresses. cles reported recent progress of this topic. Hanamura et al. Although this is due to consistent dependency on the described a potential endocrine resistance mechanism in estrogen receptor (ER) system in HR-positive breast can- breast cancer found via cell studies and animal models . cer, in later periods of ABC/MBC treatment, tumors gradu- They established six types of aromatase inhibitor-resistant ally lose the response to this type of endocrine drugs. Many breast cancer cell lines, and showed us an important issue drugs have been developed to date, and recent progress where a
Breast Cancer – Springer Journals
Published: May 28, 2018
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