Mammalian Genome 9, 491–495 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 1 2 Joseph H. Nadeau, David Sankoff Genetics Department, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, Ohio 44106-4955, USA Centre de recherches mathe ´matiques, Universite ´ de Montre ´al, CP 6128 succursale Centre-Ville, Montre ´al, Que ´bec H3C 3J7 Canada Received: 5 December 1997 / Accepted: 5 February 1998 Table 1. Examples of ‘disrupted synteny’ and ‘disrupted linkage but not synteny’ on Comparative maps of conserved chromosomal segments are im- three representative mouse chromosomes. Mouse Chrs 4, 5, and 14 Committee Maps portant data for predicting linkages, identifying candidate disease were used as sources of examples (Mock et al. 1997; Kozak and Stephenson 1997; genes, and studying genome organization and evolution. As gene Abbadi and Nadeau 1997, respectively). All segments that are #2 cm long were mapping efforts proceed, most new genes are mapped to their included. The primary literature was not evaulated to assess independently the strength of the evidence for the map locations that were determined by the experts on expected locations within known conserved chromosome seg- the Mouse Chromosome Committees. ments. It has been proposed that a random
Mammalian Genome – Springer Journals
Published: Jun 1, 1998
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