The large-scale Munich ENU-mouse-mutagenesis screen

The large-scale Munich ENU-mouse-mutagenesis screen Mammalian Genome 11, 507–510 (2000). DOI: 10.1007/s003350010097 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 1 1 1 2 1 1 Dian Soewarto, Christiane Fella, Andreas Teubner, Birgit Rathkolb, Walter Pargent, Stephan Heffner, 1 2 3 1 Susan Marschall, Eckhard Wolf, Rudi Balling, Martin Hrabe ´ de Angelis GSF Research Center, Institute of Experimental Genetics, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany Institute of Molecular Animal Breeding, Gene Center, Ludwig-Maximilian University, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany GSF Research Center, Institute for Mammalian Genetics, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany Received: 16 December 1999 / Accepted: 16 December 1999 Introduction bucil induces small deletions. These approaches have a long tra- dition in classical genetics and have generated a large number of Within the next few years the complete sequence of the human mutant phenotypes. The responsible genes are then identified genome will be available (Schuler et al. 1996), and the post- through positional cloning or other strategies. The validity and genome era will start with the systematic analysis of gene function success of these approaches were demonstrated in the course of the and its role in human pathogenesis and disease. Characterization of genetic and molecular dissection of the pathway that Mammalian Genome Springer Journals

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Copyright © 2000 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Anatomy; Zoology
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