Diabetologia (2017) 60:1712–1721 DOI 10.1007/s00125-017-4329-9 ARTICLE The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease 1,2,3 1 4 3 Eirik W. Rebnord & Elin Strand & Øivind Midttun & Gard F.T. Svingen & 1,5 1,6 1,2,7 Monika H.E. Christensen & Per M. Ueland & Gunnar Mellgren & 1,2,8 9 1,2,3 2,3 Pål R. Njølstad & Grethe S. Tell & Ottar K. Nygård & Eva R. Pedersen Received: 9 January 2017 /Accepted: 15 May 2017 /Published online: 13 June 2017 The Author(s) 2017. This article is an open access publication Abstract ation. Comparing quartile 4 with quartile 1, the HRs (95% Aims/hypothesis The tryptophan metabolite kynurenine has CIs) were 2.59 (1.56, 4.30) and 2.35 (1.39, 3.96) in the age- potent immune modulatory and vasoactive properties. and sex-adjusted and multivariate models, respectively. Experimental data implicate kynurenine in obesity-related Conclusions/interpretation Urine KTR is a strong predictor morbidities. Epidemiological studies are, however, sparse. of incident type 2 diabetes in individuals with CAD. We evaluated associations of the plasma and urine Potential clinical implications and possible pathogenic roles kynurenine:tryptophan ratio (KTR) to incident type 2 of renal kynurenine excretion in type 2 diabetes development diabetes.
Diabetologia – Springer Journals
Published: Jun 13, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud