The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease

The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in... Diabetologia (2017) 60:1712–1721 DOI 10.1007/s00125-017-4329-9 ARTICLE The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease 1,2,3 1 4 3 Eirik W. Rebnord & Elin Strand & Øivind Midttun & Gard F.T. Svingen & 1,5 1,6 1,2,7 Monika H.E. Christensen & Per M. Ueland & Gunnar Mellgren & 1,2,8 9 1,2,3 2,3 Pål R. Njølstad & Grethe S. Tell & Ottar K. Nygård & Eva R. Pedersen Received: 9 January 2017 /Accepted: 15 May 2017 /Published online: 13 June 2017 The Author(s) 2017. This article is an open access publication Abstract ation. Comparing quartile 4 with quartile 1, the HRs (95% Aims/hypothesis The tryptophan metabolite kynurenine has CIs) were 2.59 (1.56, 4.30) and 2.35 (1.39, 3.96) in the age- potent immune modulatory and vasoactive properties. and sex-adjusted and multivariate models, respectively. Experimental data implicate kynurenine in obesity-related Conclusions/interpretation Urine KTR is a strong predictor morbidities. Epidemiological studies are, however, sparse. of incident type 2 diabetes in individuals with CAD. We evaluated associations of the plasma and urine Potential clinical implications and possible pathogenic roles kynurenine:tryptophan ratio (KTR) to incident type 2 of renal kynurenine excretion in type 2 diabetes development diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Internal Medicine; Metabolic Diseases; Human Physiology
ISSN
0012-186X
eISSN
1432-0428
D.O.I.
10.1007/s00125-017-4329-9
Publisher site
See Article on Publisher Site

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