Background: To review the distribution and function of K channels, describe the use of K channels openers ATP ATP in clinical trials and make the case that these channels may play a role in headache and migraine. Discussion: K channels are widely present in the trigeminovascular system and play an important role in the ATP regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K channel openers report ATP headache as a prevalent-side effect in non-migraine sufferers, indicating that K channel opening may cause ATP headache, possibly due to vascular mechanisms. Whether K channel openers can provoke migraine in migraine ATP sufferers is not known. Conclusion: We suggest that K channels may play an important role in migraine pathogenesis and could be a ATP potential novel therapeutic anti-migraine target. Keywords: Migraine, K channel, K channels, Headache, Levcromakalim, Cromakalim ATP ATP Introduction controlling vascular tone, and protecting cells against Adenosine 5′-triphosphate-sensitive K (K ) channel metabolic stress [2, 4, 5]. ATP openers have been used in clinical trials for the treatment Over the past three decades, some preclinical evi- of hypertension and asthma. The most common side ef- dence has emerged indicating that K channels may ATP
The Journal of Headache and Pain – Springer Journals
Published: Aug 23, 2017
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