The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine Background: To review the distribution and function of K channels, describe the use of K channels openers ATP ATP in clinical trials and make the case that these channels may play a role in headache and migraine. Discussion: K channels are widely present in the trigeminovascular system and play an important role in the ATP regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K channel openers report ATP headache as a prevalent-side effect in non-migraine sufferers, indicating that K channel opening may cause ATP headache, possibly due to vascular mechanisms. Whether K channel openers can provoke migraine in migraine ATP sufferers is not known. Conclusion: We suggest that K channels may play an important role in migraine pathogenesis and could be a ATP potential novel therapeutic anti-migraine target. Keywords: Migraine, K channel, K channels, Headache, Levcromakalim, Cromakalim ATP ATP Introduction controlling vascular tone, and protecting cells against Adenosine 5′-triphosphate-sensitive K (K ) channel metabolic stress [2, 4, 5]. ATP openers have been used in clinical trials for the treatment Over the past three decades, some preclinical evi- of hypertension and asthma. The most common side ef- dence has emerged indicating that K channels may ATP http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Headache and Pain Springer Journals

The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

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Publisher
Springer Milan
Copyright
Copyright © 2017 by The Author(s).
Subject
Medicine & Public Health; Pain Medicine; Internal Medicine; Neurology
ISSN
1129-2369
eISSN
1129-2377
D.O.I.
10.1186/s10194-017-0800-8
Publisher site
See Article on Publisher Site

Abstract

Background: To review the distribution and function of K channels, describe the use of K channels openers ATP ATP in clinical trials and make the case that these channels may play a role in headache and migraine. Discussion: K channels are widely present in the trigeminovascular system and play an important role in the ATP regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K channel openers report ATP headache as a prevalent-side effect in non-migraine sufferers, indicating that K channel opening may cause ATP headache, possibly due to vascular mechanisms. Whether K channel openers can provoke migraine in migraine ATP sufferers is not known. Conclusion: We suggest that K channels may play an important role in migraine pathogenesis and could be a ATP potential novel therapeutic anti-migraine target. Keywords: Migraine, K channel, K channels, Headache, Levcromakalim, Cromakalim ATP ATP Introduction controlling vascular tone, and protecting cells against Adenosine 5′-triphosphate-sensitive K (K ) channel metabolic stress [2, 4, 5]. ATP openers have been used in clinical trials for the treatment Over the past three decades, some preclinical evi- of hypertension and asthma. The most common side ef- dence has emerged indicating that K channels may ATP

Journal

The Journal of Headache and PainSpringer Journals

Published: Aug 23, 2017

References

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