The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine Background: To review the distribution and function of K channels, describe the use of K channels openers ATP ATP in clinical trials and make the case that these channels may play a role in headache and migraine. Discussion: K channels are widely present in the trigeminovascular system and play an important role in the ATP regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K channel openers report ATP headache as a prevalent-side effect in non-migraine sufferers, indicating that K channel opening may cause ATP headache, possibly due to vascular mechanisms. Whether K channel openers can provoke migraine in migraine ATP sufferers is not known. Conclusion: We suggest that K channels may play an important role in migraine pathogenesis and could be a ATP potential novel therapeutic anti-migraine target. Keywords: Migraine, K channel, K channels, Headache, Levcromakalim, Cromakalim ATP ATP Introduction controlling vascular tone, and protecting cells against Adenosine 5′-triphosphate-sensitive K (K ) channel metabolic stress [2, 4, 5]. ATP openers have been used in clinical trials for the treatment Over the past three decades, some preclinical evi- of hypertension and asthma. The most common side ef- dence has emerged indicating that K channels may ATP The Journal of Headache and Pain Springer Journals

The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

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Springer Milan
Copyright © 2017 by The Author(s).
Medicine & Public Health; Pain Medicine; Internal Medicine; Neurology
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