Mammalian Genome 10, 934–937 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3 1 1 2 1 Stavros Malas, Sarah Duthie, Panagiotis Deloukas, Vasso Episkopou MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, UK Sanger Centre, Hinxton Hall, Cambridge CB10 1SB, UK Received: 5 February 1999 / Accepted: 29 April 1999 The SOX family of HMG-type transcription factors were discov- sis, sequencing within the HMG domain, and fluorescent in situ ered following the isolation of the mammalian sex-determining hybridization (FISH). gene, SRY (Gubbay et al. 1990). The SRY and SOX proteins share For SOX14 and SOX21, one subclone that contained the HMG a single 79-amino acid DNA-binding domain known as the HMG box was fully sequenced. Clone pCL4, a 6817-bp BamHI frag- box, which binds DNA in a sequence-specific manner (reviewed ment, was analyzed and found to include an HMG-containing ORF by Pevny and Lovell-Badge 1997). At least 28 SOX genes have at positions 4987–5709 (GenBank, Accession No. AF107044). been identified in both vertebrates and invertebrates, and several
Mammalian Genome – Springer Journals
Published: Sep 1, 1999
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