The Involvement of the Drosophila melanogaster Nuclear Protein e(y)2 in Transcription Regulation

The Involvement of the Drosophila melanogaster Nuclear Protein e(y)2 in Transcription Regulation Molecular analysis of a new evolutionarily conserved transcription factor, e(y)2, was carried out. The protein was detected in a complex of approximately 700 kDa contained in aDrosophila melanogaster transcription nuclear extract. The e(y)2 protein was shown to interact with components of the preinitiation transcription complex TFIID. Addition of e(y)2 to a transcription extract of HeLa cells increased transcription 4–5 times when chromatin, but not free DNA, was used as a template. Genetic analysis showed that the C-terminal amino acid residues of transcription factor TAFII40 are important for its interaction with e(y)2. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

The Involvement of the Drosophila melanogaster Nuclear Protein e(y)2 in Transcription Regulation

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1009010307221
Publisher site
See Article on Publisher Site

Abstract

Molecular analysis of a new evolutionarily conserved transcription factor, e(y)2, was carried out. The protein was detected in a complex of approximately 700 kDa contained in aDrosophila melanogaster transcription nuclear extract. The e(y)2 protein was shown to interact with components of the preinitiation transcription complex TFIID. Addition of e(y)2 to a transcription extract of HeLa cells increased transcription 4–5 times when chromatin, but not free DNA, was used as a template. Genetic analysis showed that the C-terminal amino acid residues of transcription factor TAFII40 are important for its interaction with e(y)2.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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