Curr Pediatr Rep (2017) 5:150–155 DOI 10.1007/s40124-017-0140-9 OBESITY (S ARMSTRONG AND A PATEL, SECTION EDITORS) 1 1 2,3 4 Jessica McCann & John Rawls & Patrick Seed & Sarah Armstrong Published online: 2 August 2017 Springer Science+Business Media, LLC 2017 Abstract capacity to understand the composition and phenotype of the Purpose of Review Pediatric obesity has reached epidemic gut microbiome and mechanistic factors that modulate human proportions worldwide. The community of microbes health. inhabiting the human intestine affects differential nutrient ab- Summary The human intestinal microbiome is associated sorption, metabolism, and weight status. However, the major- with both the environment and child obesity. Understanding ity of our knowledge is derived from animal models and adults the mechanisms behind microbial regulation of human metab- with obesity. This review discusses the role of the intestinal olism during infancy and childhood is key to developing ef- microbiome in the development and modification of pediatric fective prevention and treatment of obesity. obesity, with a focus on opportunities for modification of the . . . microbiome through alteration of environmental factors. Keywords Microbiome Pediatric obesity Dysbiosis Recent Findings Recent evidence suggests that obesity is as- Intestinal bacteria sociated with phylogenetic changes in the gut
Current Pediatrics Reports – Springer Journals
Published: Aug 2, 2017
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