The interplay between bone and vessels in pediatric CKD: lessons from a single-center study

The interplay between bone and vessels in pediatric CKD: lessons from a single-center study Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quan- titative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.73m (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32– 116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Nephrology Springer Journals

The interplay between bone and vessels in pediatric CKD: lessons from a single-center study

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by IPNA
Subject
Medicine & Public Health; Pediatrics; Nephrology; Urology
ISSN
0931-041X
eISSN
1432-198X
D.O.I.
10.1007/s00467-018-3978-3
Publisher site
See Article on Publisher Site

Abstract

Objective Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. Methods This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quan- titative computed tomography (HR-pQCT) at the ultra-distal tibia. Results are presented as median (range). Results At a median age of 12.9 years (10.2–17.9), SDS height of − 1.0 (− 3.3–1.2) and estimated glomerular filtration rate (eGFR) of 33 mL/min/1.73m (11–72), 32 patients (8 girls) were evaluated. Median calcium, phosphate, parathyroid hormone (PTH), and 25 OHD3 levels were 2.44 mmol/L (2.24–2.78), 1.43 mmol/L (1.0–2.7), 80 pg/mL (9–359), and 70 nmol/L (32– 116), respectively. Bivariate Spearman and backward multivariable analyses showed that calcium and bone trabecular thickness (Tb.Th), were positively associated with diastolic and mean arterial blood pressure (both for the 24 h, day and night assessment), whereas PTH and vitamin D did not predict blood pressure. Conclusions We show that the

Journal

Pediatric NephrologySpringer Journals

Published: Jun 5, 2018

References

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