The absence of toxic properties and genotoxic activity was shown for water-soluble pillararenes containing amide and ammonium fragments. There was no induced mutation associated with the substitution of base pairs in the Ames test. Using the methods of turbidimetry and transmitting electron microscopy (TEM), the interaction of the macrocycle with the surface of lipid bilayer in the liquid crystalline state was established. DLS detected the appearance of larger particles upon titration of liposome suspension with pillararene 3. TEM confirms an increase in the average diameter of liposomes in the presence of the macrocycle which may result from liposome fusion.
BioNanoScience – Springer Journals
Published: May 30, 2018
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