The Interaction of Water-Soluble Pillar[5]Arenes Containing Amide and Ammonium Fragments with Lipid Bilayer

The Interaction of Water-Soluble Pillar[5]Arenes Containing Amide and Ammonium Fragments with... The absence of toxic properties and genotoxic activity was shown for water-soluble pillar[5]arenes containing amide and ammonium fragments. There was no induced mutation associated with the substitution of base pairs in the Ames test. Using the methods of turbidimetry and transmitting electron microscopy (TEM), the interaction of the macrocycle with the surface of lipid bilayer in the liquid crystalline state was established. DLS detected the appearance of larger particles upon titration of liposome suspension with pillar[5]arene 3. TEM confirms an increase in the average diameter of liposomes in the presence of the macrocycle which may result from liposome fusion. . . . Keywords Pillar[5]arene Self-assembly Toxicity Macrocyclic receptors 1 Introduction Pillar[5]arene as homolog, obtained with a high yield and known properties [5], is able to form inclusion complexes The development of new systems of molecular recognition with various biologically important substrates [8]. In this con- is one of the promising areas of modern supramolecular nection, it is particularly interesting to study the interactions of chemistry [1–3]. In recent years, the research of a new functionalized water-soluble pillar[5]arenes with the bilayer class of paracyclophanes—the Pillar[n]arenes—has of the model membrane for determining the ability of these attracted considerable interest [4, 5]. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioNanoScience Springer Journals

The Interaction of Water-Soluble Pillar[5]Arenes Containing Amide and Ammonium Fragments with Lipid Bilayer

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Engineering; Circuits and Systems; Biological and Medical Physics, Biophysics; Nanotechnology; Biomaterials
ISSN
2191-1630
eISSN
2191-1649
D.O.I.
10.1007/s12668-018-0532-5
Publisher site
See Article on Publisher Site

Abstract

The absence of toxic properties and genotoxic activity was shown for water-soluble pillar[5]arenes containing amide and ammonium fragments. There was no induced mutation associated with the substitution of base pairs in the Ames test. Using the methods of turbidimetry and transmitting electron microscopy (TEM), the interaction of the macrocycle with the surface of lipid bilayer in the liquid crystalline state was established. DLS detected the appearance of larger particles upon titration of liposome suspension with pillar[5]arene 3. TEM confirms an increase in the average diameter of liposomes in the presence of the macrocycle which may result from liposome fusion. . . . Keywords Pillar[5]arene Self-assembly Toxicity Macrocyclic receptors 1 Introduction Pillar[5]arene as homolog, obtained with a high yield and known properties [5], is able to form inclusion complexes The development of new systems of molecular recognition with various biologically important substrates [8]. In this con- is one of the promising areas of modern supramolecular nection, it is particularly interesting to study the interactions of chemistry [1–3]. In recent years, the research of a new functionalized water-soluble pillar[5]arenes with the bilayer class of paracyclophanes—the Pillar[n]arenes—has of the model membrane for determining the ability of these attracted considerable interest [4, 5].

Journal

BioNanoScienceSpringer Journals

Published: May 30, 2018

References

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