The effect of Drosophilamutation rad201 G1together with mutations mei-41 D5and mei-9 aon the sensitivity of oocytes to induction of dominant lethals (DLs) was studied. To this end, the frequencies of spontaneous and gamma-radiation-induced DLs in consecutive egg batches of females carrying double or single mutations were estimated. Since the effects of the mutations examined are expressed only at the previtellogenetic stages of oogenesis, only newly hatched (0–5-hour-old) females, whose oocytes did not develop farther than stage 7, were irradiated. The results obtained indicated that in intact and irradiated oocytes of double mutants mei-9 a rad201 G1and mei-41 D5 rad201 G1, mutation rad201 G1epistatically suppresses the mutations of the both meigenes.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
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