The Insulin Signaling Pathway

The Insulin Signaling Pathway J. Membrane Biol. 169, 1–12 (1999) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1999 Topical Review 1,2 1,2 C. Taha , A. Klip Programme in Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8 Canada Received: 5 November 1998/Revised: 4 February 1999 Introduction the b-subunit is a transmembrane peptide (Van Ob- berghen et al., 1981). The intracellular portion of the Insulin mediates a wide spectrum of biological responses b-subunit contains the insulin-regulated tyrosine protein including stimulation of glucose uptake, glycogen, lipid kinase (Kasuga et al., 1983). Insulin binding activates and protein synthesis, antilipolysis, activation of tran- the tyrosine kinase leading to autophosphorylation of ty- scription of specific genes, and modulation of cellular rosine residues in several regions of the intracellular growth and differentiation. Since the discovery of insu- b-subunit and the tyrosine phosphorylation of the IRS- lin 77 years ago, great progress has been made in under- proteins. The reader is referred to an in-depth review on standing the diverse signaling pathways that emanate the structure of the insulin receptor (White, 1997). from the insulin receptor itself to generate the pleiotropic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

The Insulin Signaling Pathway

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1999 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/PL00005896
Publisher site
See Article on Publisher Site

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