J. Membrane Biol. 177, 1–11 (2000) The Journal of DOI: 10.1007/s002320001096 Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review 1 2 H.J. Worman , J.-C. Courvalin Departments of Medicine and of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA De ´partement de Biologie Cellulaire, Institut Jacques Monod, CNRS, Universite ´ Paris 7, Paris, France Received: 10 February 2000/Revised: 11 May 2000 Introduction carboxyl-terminal tail domains separated by alpha- helical rod domains that are highly conserved among all The nuclear envelope surrounds the cell nucleus and is intermediate filament proteins (Franke, 1987). The nuclear lamins form the nuclear lamina, a meshwork of composed of the nuclear lamina, nuclear pore complexes and nuclear membranes (Fig. 1). The nuclear membrane intermediate filaments on the inner surface of the inner nuclear membrane. is divided into three distinct but interconnected domains: outer, pore and inner. The outer nuclear membrane is Nuclear lamins have been identified in many differ- ent metazoan species (Erber et al., 1999). In humans, directly continuous with and similar in composition to three genetic loci encode lamins (Biamonte et al., 1992; the endoplasmic reticulum membrane. The pore mem- branes connect the
The Journal of Membrane Biology – Springer Journals
Published: Sep 1, 2000
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