The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

The influence of the milieu on the rate of neutralisation of herpes simplex virus 1 The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is ‘dilution-fast’ under physiological conditions of transudation or pathological conditions of inflammation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

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Publisher
Springer-Verlag
Copyright
Copyright © Wien by 1998 Springer-Verlag/
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050050310
Publisher site
See Article on Publisher Site

Abstract

The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is ‘dilution-fast’ under physiological conditions of transudation or pathological conditions of inflammation.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 1998

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