We have shown previously that the polymorphic structure of the limk1 gene in Drosophila leads to changes in LIMK1 content and to defects in courtship behavior, sound production, and learning/memory. The results of the present study of three wild-type strains and mutant agn ts3 with altered limk1 structure demonstrate that long-term memory is normal in Canton-S and Oregon-R but is impaired in Berlin and drastically suppressed in agn ts3 . This temperature-sensitive mutant carries the S-element from the Tc1/mariner family insertion near the dlimk1 3′-UTR and, compared to Canton-S, has a reverse pCREB distribution in adult neuromuscular junctions (NMJ) of the second dorsal imago nerve before and after learning. Moreover, only agn ts3 demonstrates amyloid-like aggregate formation in NMJ. This suggests that this impedes pCREb transport and thereby impairs the formation of short- and long-term memory.
Russian Journal of Genetics – Springer Journals
Published: Jul 7, 2015
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