The influence of systemic renin-angiotensin-inhibition on ocular cytokines related to proliferative vitreoretinopathy

The influence of systemic renin-angiotensin-inhibition on ocular cytokines related to... Purpose The renin-angiotensin system is involved in the sion does not influence levels of profibrotic cytokines/growth pathogenesis of fibrosis in several organs via induction of factors in aqueous humor. Further studies need to clarify if rele- transforming growth factor (TGF) beta. In the pathogenesis vant levels of ACEI accumulate in the eye, and if direct admin- of proliferative vitreoretinopathy (PVR) TGF-beta plays a piv- istration of ACEI in experimental PVR could be beneficial. otal role, promoting transition of retinal pigment epithelial . . (RPE) cells into myofibroblasts. We studied the influence of Keywords Proliferative vitreoretinopathy Treatment . . . angiotensin converting enzyme-inhibition (ACEI) on cyto- Angiotensin converting enzyme Renin Cytokines Growth kines and growth factors, related to PVR in aqueous humor. factors Methods We performed a post hoc analysis of a prospectively conducted interventional case series. From patients with rhegmatogenous retinal detachment (RRD) aqueous humor Introduction was obtained during primary surgery and analyzed using mul- tiplex bead analysis for interferon gamma, tumor necrosis fac- Proliferative vitreoretinopathy (PVR) is the leading cause for tor alpha, CC-chemokine ligand (CCL) 2 / monocyte failure of vitreoretinal surgery [1, 2]. Transforming growth chemoattractant protein (MCP)-1, interleukin (IL)-1 beta, IL- factor (TGF) beta plays Graefe's Archive for Clinical and Experimental Ophthalmology Springer Journals

The influence of systemic renin-angiotensin-inhibition on ocular cytokines related to proliferative vitreoretinopathy

Loading next page...
Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Ophthalmology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial