J Cancer Res Clin Oncol (2017) 143:1891–1903 DOI 10.1007/s00432-017-2442-2 ORIGINAL ARTICLE – CLINICAL ONCOLOGY The influence of local therapy on the survival of patients with metastatic rectal cancer: a population‑based, propensity‑matched study 1 2 3 4 1 Chi‑Hao Zhang · Yuan‑Bo Pan · Qing‑Wei Zhang · Ou‑Min Shi · Lei Zheng · 1 5 Liang Gui · Meng Luo Received: 11 May 2017 / Accepted: 17 May 2017 / Published online: 22 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract Results Of 6867 patients included in this analysis, 3971 Purpose This study was aimed to determine the effect of (57.8%) received local therapy to the primary tumor and the local tumor therapy on patients’ prognosis in the man- 2896 (42.2%) did not receive. Both univariable and mul- agement of metastatic rectal cancer. tivariable analysis showed local therapy continued to Methods Patients diagnosed with metastatic rectal cancer be associated with an improvement in OS (HR 0.532; from 2004 to 2013 were selected from the SEER (Surveil- 95% CI 0.503–0.563, p < 0.001 and HR 0.532; 95% CI lance, Epidemiology, and End Results) database. Over- 0.498–0.568, p < 0.001, respectively) and CSS (HR 0.527; all survival and cancer-specific survival were compared
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: May 22, 2017
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