The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia

The influence of host factors and sequence variability of the p7 region on the response to... The goal of this study was to identify host and viral factors affecting the response to pegylated interferon/ribavirin (PEG-IFN/RBV) treatment in patients with chronic hepatitis C genotype 1b. Baseline characteristics of the patients and sequences within the p7 region were analyzed in pre-treatment serum samples from 53 individuals with chronic hepatitis C genotype 1b and related to the outcome of therapy. We found a significant correlation between age and response to therapy ( p < 0.001). Furthermore, the pre-treatment viral load was closely associated with the stage of liver fibrosis ( p < 0.001). The presence of fewer than 4 mutations and age above 40 were significantly associated with non-response (NR) ( p < 0.001). Our findings may be useful for estimating the likelihood of achieving a sustained virologic response (SVR) in patients who are chronically infected with hepatitis C virus genotype 1b. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

The influence of host factors and sequence variability of the p7 region on the response to pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b in patients from Serbia

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Publisher
Springer Vienna
Copyright
Copyright © 2016 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-016-2777-z
Publisher site
See Article on Publisher Site

Abstract

The goal of this study was to identify host and viral factors affecting the response to pegylated interferon/ribavirin (PEG-IFN/RBV) treatment in patients with chronic hepatitis C genotype 1b. Baseline characteristics of the patients and sequences within the p7 region were analyzed in pre-treatment serum samples from 53 individuals with chronic hepatitis C genotype 1b and related to the outcome of therapy. We found a significant correlation between age and response to therapy ( p < 0.001). Furthermore, the pre-treatment viral load was closely associated with the stage of liver fibrosis ( p < 0.001). The presence of fewer than 4 mutations and age above 40 were significantly associated with non-response (NR) ( p < 0.001). Our findings may be useful for estimating the likelihood of achieving a sustained virologic response (SVR) in patients who are chronically infected with hepatitis C virus genotype 1b.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2016

References

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  • Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production
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  • Analogy of human immunodeficiency virus to hepatitis C virus: the human immunodeficiency model
    Pollard, RB
  • A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel
    Cornberg, M; Razavi, HA; Alberti, A; Bernasconi, E; Buti, M; Cooper, C; Dalgard, O; Dillion, JF; Flisiak, R; Forns, X; Frankova, S; Goldis, A; Goulis, I; Halota, W; Hunyady, B; Lagging, M; Largen, A; Makara, M; Manolakopoulos, S; Marcellin, P; Marinho, RT; Pol, S; Poynard, T; Puoti, M; Sagalova, O; Sibbel, S; Simon, K; Wallace, C; Young, K; Yurdaydin, C; Zuckerman, E; Negro, F; Zeuzem, S
  • Secondary structure, dynamics, and architecture of the p7 membrane protein from hepatitis C virus by NMR spectroscopy
    Cook, GA; Opella, SJ
  • Hepatitis C virus p7: molecular function and importance in hepatitis C virus life cycle and potential antiviral target
    Khaliq, S; Jahan, S; Hassan, S

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