The influence of elevated hormone levels on physiologic accumulation of 68Ga-DOTATOC

The influence of elevated hormone levels on physiologic accumulation of 68Ga-DOTATOC 68 1 3 Objective PET/CT imaging with Ga-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid-D-Phe -Tyr -octreotide (DOTATOC) is useful in patients with neuroendocrine tumors (NETs). Functioning NETs by definition secrete abnormal levels of hormones, causing clinical symptoms. It is known that physiologic accumulation can be seen in some organs, but it remains unknown whether elevated hormone levels can affect the physiologic accumulation pattern of Ga-DOTATOC. We aimed to investigate the influence of higher hormone levels on physiologic accumulation of Ga-DOTATOC. Methods A total of 167 patients with known or suspected NET lesions were enrolled in this study. The numbers of patients with elevations of ACTH, gastrin, insulin, and no elevation were 10, 25, 7, and 125, respectively. We compared the maximum standardized uptake value (SUVmax) in various organs of each group. Results In the group with elevated ACTH levels, SUVmax in the pituitary gland, the uncinate process of the pancreas and adrenal glands was lower than those in the group with no elevation (5.7 ± 1.9 vs. 8.4 ± 3.1, P = 0.015; 4.7 ± 3.5 vs. 6.4 ± 2.8, P = 0.037; 10.8 ± 4.8 vs. 13.9 ± 4.7, P = 0.020, respectively). There were no differences in physiologic uptake of Ga- DOTATOC http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Nuclear Medicine Springer Journals

The influence of elevated hormone levels on physiologic accumulation of 68Ga-DOTATOC

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Publisher
Springer Japan
Copyright
Copyright © 2018 by The Japanese Society of Nuclear Medicine
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology
ISSN
0914-7187
eISSN
1864-6433
D.O.I.
10.1007/s12149-018-1233-4
Publisher site
See Article on Publisher Site

Abstract

68 1 3 Objective PET/CT imaging with Ga-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid-D-Phe -Tyr -octreotide (DOTATOC) is useful in patients with neuroendocrine tumors (NETs). Functioning NETs by definition secrete abnormal levels of hormones, causing clinical symptoms. It is known that physiologic accumulation can be seen in some organs, but it remains unknown whether elevated hormone levels can affect the physiologic accumulation pattern of Ga-DOTATOC. We aimed to investigate the influence of higher hormone levels on physiologic accumulation of Ga-DOTATOC. Methods A total of 167 patients with known or suspected NET lesions were enrolled in this study. The numbers of patients with elevations of ACTH, gastrin, insulin, and no elevation were 10, 25, 7, and 125, respectively. We compared the maximum standardized uptake value (SUVmax) in various organs of each group. Results In the group with elevated ACTH levels, SUVmax in the pituitary gland, the uncinate process of the pancreas and adrenal glands was lower than those in the group with no elevation (5.7 ± 1.9 vs. 8.4 ± 3.1, P = 0.015; 4.7 ± 3.5 vs. 6.4 ± 2.8, P = 0.037; 10.8 ± 4.8 vs. 13.9 ± 4.7, P = 0.020, respectively). There were no differences in physiologic uptake of Ga- DOTATOC

Journal

Annals of Nuclear MedicineSpringer Journals

Published: Jan 18, 2018

References

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