The Influence and Delivery of Cytokines and their Mediating Effect on Muscle Satellite Cells

The Influence and Delivery of Cytokines and their Mediating Effect on Muscle Satellite Cells Purpose of Review Skeletal muscle satellite cells (SC) play an tween capillaries and muscle SC highlights the importance important role in the adaptation, repair, and maintenance of of this anatomical relationship on SC function in response to muscle. These resident muscle stem cells are regulated by a physiological stimuli. series of transcription factors known as myogenic regulator . . factors that orchestrate SC progression from the quiescent Keywords Satellite cells Myogenic program . . state through activation, proliferation, and differentiation, ul- Capillarization Inflammation Cytokine timately leading to the contribution of nuclei to muscle fibers. The purpose of this review was to provide an overview of the current state of knowledge on the role of cytokines in regulat- Introduction ing muscle SC. Recent Findings Upstream effectors of the myogenic regula- Skeletal muscle accounts for nearly 40% of all human tissue tory factors include growth factors and cytokines that can and is responsible for locomotion, posture, and breathing. influence SC function through autocrine/paracrine signaling Additionally, skeletal muscle plays an important metabolic delivered via the microvasculature and general circulation, or role as it serves as a major storage site for glucose and is the through cell interactions with other muscle-resident cells and Current Stem Cell Reports Springer Journals

The Influence and Delivery of Cytokines and their Mediating Effect on Muscle Satellite Cells

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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Life Sciences; Cell Biology; Stem Cells
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