The increase in the proportion of nervous animals bred for catatonia: The participation of central adrenoreceptors in catatonic reactions

The increase in the proportion of nervous animals bred for catatonia: The participation of... Using a large amount of breeding material, the idea of D.K. Belyaev on the role of selection in the appearance of new behavioral and neuronal forms was confirmed. Experiments were performed using rats of the GC (genetics + catatonia) strain, which are prone to passive defensive reactions of cataleptic freezing. At the current breeding stage, elevation of the proportion of so-called “nervous” animals was demonstrated, both with respect to the expression of such reactions and their frequency. At this breeding stage, in the brains of GC rats, the mRNA levels of α1A- and α2A-adrenoreceptor genes were determined. A decrease of α1A-adrenoreceptor gene expression in the midbrain and medulla oblongata, along with elevation of α2A-adreno-receptor gene expression in the frontal cortex was observed. It was suggested that changes in the expression of α-adrenoreceptor genes could be caused by an increase in the proportion of nervous animals and could contribute to the akinetic behavioral component in GC rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

The increase in the proportion of nervous animals bred for catatonia: The participation of central adrenoreceptors in catatonic reactions

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Publisher
Springer Journals
Copyright
Copyright © 2012 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Human Genetics; Animal Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795412100092
Publisher site
See Article on Publisher Site

Abstract

Using a large amount of breeding material, the idea of D.K. Belyaev on the role of selection in the appearance of new behavioral and neuronal forms was confirmed. Experiments were performed using rats of the GC (genetics + catatonia) strain, which are prone to passive defensive reactions of cataleptic freezing. At the current breeding stage, elevation of the proportion of so-called “nervous” animals was demonstrated, both with respect to the expression of such reactions and their frequency. At this breeding stage, in the brains of GC rats, the mRNA levels of α1A- and α2A-adrenoreceptor genes were determined. A decrease of α1A-adrenoreceptor gene expression in the midbrain and medulla oblongata, along with elevation of α2A-adreno-receptor gene expression in the frontal cortex was observed. It was suggested that changes in the expression of α-adrenoreceptor genes could be caused by an increase in the proportion of nervous animals and could contribute to the akinetic behavioral component in GC rats.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Nov 17, 2012

References

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