Short Communications Incorporating Mouse Genome Mammalian Genome 10, 182–185 (1999). © Springer-Verlag New York Inc. 1999 The imprinted domain in mouse distal Chromosome 7: reagents for mutagenesis and sequencing Colleen D. Day, Nancy J. Smilinich, Galina V. Fitzpatrick, Pieter J. deJong, Thomas B. Shows, Michael J. Higgins Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA Received: 18 August 1998 / Accepted: 1 October 1998 Several lines of evidence suggest that human Chromosome (Chr) mouse imprinted domain for comparative studies. We also report band 11p15.5 contains genes involved in tumor suppression and the mapping of the Orctl2, the mouse orthologue of ORCTL2, a embryonic growth (reviewed in Reid et al. 1997 and Cooper et al. novel murine gene represented by several expressed sequence tags 1998). First, rare chromosomal breakpoints in Beckwith- (ESTs), as well as 10 new sequence tagged sites (STSs) corre- Wiedemann syndrome (BWS) patients and pediatric tumors map sponding to ends of PAC clone inserts. to 11p15.5. Since BWS patients suffer from a variety of over- The RPCI-21 mouse (129/SvEvTACfBr) PAC library consist- growth disorders and predisposition to embryonic tumors includ- ing of more than 125,000 clones (avg. size, 127 kb) and represent-
Mammalian Genome – Springer Journals
Published: Feb 1, 1999
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