The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths

The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths Curr Diab Rep (2017) 17:87 DOI 10.1007/s11892-017-0917-9 OBESITY (J MCCAFFERY, SECTION EDITOR) The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths 1 2 1,3,4 Madhur Agrawal & Philip A. Kern & Barbara S. Nikolajczyk Springer Science+Business Media, LLC 2017 Abstract of metabolically-associated inflammation, or meta- Purpose of Review Adipose tissue (AT) houses both innate flammation. and adaptive immune systems that are crucial for preserving Summary More studies are required to recognize factors that AT function and metabolic homeostasis. In this review, we switch inflammation from controlled to uncontrolled in summarize recent information regarding progression of obesity-associated pathogenesis and to integrate the combined obesity-associated AT inflammation and insulin resistance. effects of meta-flammation and immunometabolism. It is crit- We additionally consider alterations in AT distribution and ical to recognize that the AT-associated immune system can be the immune system in males vs. females and among different alternately beneficial and destructive; therefore, simply racial populations. blocking immune responses early in obesity may not be the Recent Findings Innate and adaptive immune cell- best clinical approach. The dearth of information on gender derived inflammation drives insulin resistance both lo- and race-associated disparities in metabolism, AT distribution, cally and systemically. However, new evidence http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Diabetes Reports Springer Journals

The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths

Loading next page...
 
/lp/springer_journal/the-immune-system-in-obesity-developing-paradigms-amidst-inconvenient-ObHlr3OYS1
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Diabetes
ISSN
1534-4827
eISSN
1539-0829
D.O.I.
10.1007/s11892-017-0917-9
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial