Mammalian Genome 8, 42-44 (1997). 9 Springer-Verlag N~w York Inc. 1997 J.C. Sowden, 1 K. Morrison, 1 W. Putt, 1 R. Beddington, 2 Y.H. Edwards I XMRC Human Biochemical Genetics Unit, The Galton Laboratory (UCL), Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK 2National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK Received: 12 June 1996 / Accepted: 6 September 1996 A large number of human eDNA clones have been sequenced, and The notochord is an example of an early embryonic organ that over 400,000 expressed sequence tags (ESTs) representing a sig- is difficult to study in humans. It is, however, the primary axial nificant proportion of the coding component of the human genome structure in the developing vertebrate embryo and is important for have been submitted to public databases. However, a number of the development of somites (Brand-Saberi et al. 1993), the floor genes are expressed only at early stages of embryogenesis and, plate of the neural tube (Placzek et al. 1993), and subsequently the since these stages are inaccessible in humans, are not currently spinal cord and motor neurones (Yamada et al. 1991). The genetic represented in cDNA libraries and sequence databases.
Mammalian Genome – Springer Journals
Published: Mar 23, 2009
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