Mammalian Genome 9, 165-167 (1998). Mammalian Genome © Springer-Verlag New York Inc. 1998 The human ZBP-89 homolog, located at Chromosome 3g21, represses gastrin gene expression S.A. Tarle, l Juanita L. Merchant' D.J. Law,' 'Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA 'Departments of Internal Medicine and Physiology, 1150 West Medical Drive, MSRBI, 3510, University of Michigan, Ann Arbor, Michigan 48109-0650, USA Received: 8 July 1997 / Accepted: 22 October 1997 Rat ZBP-89 cDNA encodes an 89-kDa, zinc finger protein that ment from B469N19 was sequenced and used to develop an STS binds a GC-rich element in the human gastrin promoter. This (374F/794R) for PCR-based screening of the human CEPH YAC element modulates both basal- and epidermal growth factor DNA matrix pools (Research Genetics, Huntsville, Ala.). The re- (EGF)-induction of gastrin gene expression (Merchant et al. 1995). sulting YAC/BAC contig shows that the human ZBP-89 gene Coexpression of ZBP-89 and gastrin reporter constructs blocks maps to chromosome band 3g21 (144-146 cM on the genetic map) EGF induction and represses basal gastrin gene expression (Mer- and, more precisely, is within 100 kb of D3S1551. This agrees with chant et al. 1996). Rat ZBP-89 similarly binds to and
Mammalian Genome – Springer Journals
Published: Mar 28, 2009
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