Mammalian Genome 9, 78-80 (1998). Mammalian Genome IncorporatlnR Mouse Genomc Springer-Verlag New York Inc. 1998 The human rab GDI 3 gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13 Zdenek Sedlacek,' Ewald Munstermann, l Antoaneta Mincheva, 2 Peter Lichter, 2 Annemarie Poustka' 'Division of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Division of Organisation of Complex Genomes, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany Received: June 1997 / Accepted: 26 August 1997 The rab GDP-dissociation inhibitors (rab GDIs) modulate the ac- with the rab GDI 13 cDNA probe GB6 (Bachner et al. 1995). Two tivity of G-proteins of the rab family and play a role in the regu- positive clones were identified, ICRFP700EO78 (E078) and lation of vesicle-mediated cellular transport (Simons and Zerial ICRFP70OB 1787 (B 1787). The EcoRl and Pstl digests of these 1993). The sequences of rab GDIs are highly conserved even clones were rescreened with the same probe, giving different pat- between animals and plants. In mammals there are at least two terns of positively hybridizing bands. A library of Pstl subclones forms of rab GDIs, the a and the 13 form. We have previously of both P1 clones
Mammalian Genome – Springer Journals
Published: Mar 28, 2009
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