Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (FcγR)-like proteins that thwart the Fcγ-mediated effector functions. Our aim was to determine whether GM allotypes—immunoglobulin γ chain determinants expressed primarily on the Fc segment—modulate this viral strategy through differential binding to the viral FcγR. Results of our ELISA binding studies show that the mean absorbance values for binding to the HCMV TRL11/IRL11 -encoded FcγR were higher for IgG1 expressing the GM 3 allotype than for those expressing the allelic GM 1,2,17 determinants ( p = 0.0005), a finding with potential implications for genetic etiology of HCMV-associated diseases.
Archives of Virology – Springer Journals
Published: May 1, 2011
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