The human cytomegalovirus TRL11/IRL11 -encoded FcγR binds differentially to allelic variants of immunoglobulin G1

The human cytomegalovirus TRL11/IRL11 -encoded FcγR binds differentially to allelic variants of... Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (FcγR)-like proteins that thwart the Fcγ-mediated effector functions. Our aim was to determine whether GM allotypes—immunoglobulin γ chain determinants expressed primarily on the Fc segment—modulate this viral strategy through differential binding to the viral FcγR. Results of our ELISA binding studies show that the mean absorbance values for binding to the HCMV TRL11/IRL11 -encoded FcγR were higher for IgG1 expressing the GM 3 allotype than for those expressing the allelic GM 1,2,17 determinants ( p = 0.0005), a finding with potential implications for genetic etiology of HCMV-associated diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

The human cytomegalovirus TRL11/IRL11 -encoded FcγR binds differentially to allelic variants of immunoglobulin G1

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Biomedicine; Medical Microbiology ; Infectious Diseases; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-011-0937-8
Publisher site
See Article on Publisher Site

Abstract

Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (FcγR)-like proteins that thwart the Fcγ-mediated effector functions. Our aim was to determine whether GM allotypes—immunoglobulin γ chain determinants expressed primarily on the Fc segment—modulate this viral strategy through differential binding to the viral FcγR. Results of our ELISA binding studies show that the mean absorbance values for binding to the HCMV TRL11/IRL11 -encoded FcγR were higher for IgG1 expressing the GM 3 allotype than for those expressing the allelic GM 1,2,17 determinants ( p = 0.0005), a finding with potential implications for genetic etiology of HCMV-associated diseases.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2011

References

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