Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Cornelius, O. MacDougald, M Lane (1994)
Regulation of adipocyte development.Annual review of nutrition, 14
J. William, RoeslerS, R. George, Vandenbark, Richard, W., Hanson (1988)
Cyclic AMP and the induction of eukaryotic gene transcription.The Journal of biological chemistry, 263 19
Clayton Hunt, J. Ro, Deborah Dobson, H. Min, Bruce Spiegelman (1986)
Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.Proceedings of the National Academy of Sciences of the United States of America, 83 11
A. Martín-Hidalgo, C. Holm, P. Belfrage, M. Schotz, E. Herrera (1994)
Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy.The American journal of physiology, 266 6 Pt 1
Juerg Rentsch, M. Chiesi (1996)
Regulation of ob gene mRNA levels in cultured adipocytesFEBS Letters, 379
T. Ryden, K. Beemon (1989)
Avian retroviral long terminal repeats bind CCAAT/enhancer-binding proteinMolecular and Cellular Biology, 9
Shuanghong Wei, K. Lai, Shailja Patel, R. Piantedosi, H. Shen, V. Colantuoni, F. Kraemer, W. Blaner (1997)
Retinyl Ester Hydrolysis and Retinol Efflux from BFC-1β Adipocytes*The Journal of Biological Chemistry, 272
M. Zennaro, N. Farman, J. Bonvalet, M. Lombès (1997)
Tissue-Specific Expression of α and β Messenger Ribonucleic Acid Isoforms of the Human Mineralocorticoid Receptor in Normal and Pathological StatesThe Journal of Clinical Endocrinology and Metabolism, 82
Fredric Kraemer, K. Tavangar, Andrew Hoffman (1991)
Developmental regulation of hormone-sensitive lipase mRNA in the rat: changes in steroidogenic tissues.Journal of lipid research, 32 8
J. Egan, A. Greenberg, Mingzhi Chang, S. Wek, M. Moos, C. Londos (1992)
Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet.Proceedings of the National Academy of Sciences of the United States of America, 89
M. Kozak (1987)
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.Nucleic acids research, 15 20
G. Rautmann, Richard Breathnach (1985)
A role for branchpoints in splicing in vivoNature, 315
M. Zennaro, N. Farman, J. Bonvalet, M. Lombès (1997)
Tissue-specific expression of alpha and beta messenger ribonucleic acid isoforms of the human mineralocorticoid receptor in normal and pathological states.The Journal of clinical endocrinology and metabolism, 82 5
P. Talmud, J. Palmen, M. Walker (1998)
Identification of genetic variation in the human hormone-sensitive lipase gene and 5' sequences: homology of 5' sequences with mouse promoter and identification of potential regulatory elements.Biochemical and biophysical research communications, 252 3
K. Caron, Y. Ikeda, Shiu Soo, D. Stocco, K. Parker, B. Clark (1997)
Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein.Molecular endocrinology, 11 2
Adisak Suwanickul, S. Morris, D. Powell (1993)
Identification of an insulin-responsive element in the promoter of the human gene for insulin-like growth factor binding protein-1.The Journal of biological chemistry, 268 23
Zhangzhi Hu, Li Zhuang, M. Dufau (1996)
Multiple and Tissue-specific Promoter Control of Gonadal and Non-gonadal Prolactin Receptor Gene Expression (*)The Journal of Biological Chemistry, 271
Cecilia Holm, Per Belfrage, G. Fredrikson (1989)
Human adipose tissue hormone-sensitive lipase: identification and comparison with other species.Biochimica et biophysica acta, 1006 2
H. Min, B. Spiegelman (1986)
Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor.Nucleic acids research, 14 22
G. Fredrikson, Hans Tornqvist, P. Belfrage (1986)
Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol.Biochimica et biophysica acta, 876 2
P. Strålfors, H. Olsson, P. Belfrage (1987)
6 Hormone-Sensitive LipaseThe Enzymes, 18
L. Holst, Dominique Langin, Hindrik Mulder, Henrik Laurell, Jacques Grober, Anders Bergh, H. Mohrenweiser, Gudrun Edgren, Cecilia Holm (1996)
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.Genomics, 35 3
C. Sztalryd, F. Kraemer (1995)
Regulation of hormone-sensitive lipase in streptozotocin-induced diabetic rats.Metabolism: clinical and experimental, 44 11
Cecilia Holm, Todd Kirchgessner, Karen Svenson, G. Fredrikson, S. Nilsson, CG Miller, JE Shively, C. Heinzmann, Robert Sparkes, T. Mohandas (1988)
Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3.Science, 241 4872
A. Rémaury, H. Laurell, J. Grober, S. Reynisdottir, M. Dauzats, C. Holm, D. Langin (1995)
Expression of hormone-sensitive lipase in the human colon adenocarcinoma cell line HT29.Biochemical and biophysical research communications, 207 1
Dominique Langin, Henrik Laurell, L. Holst, Per Belfrage, Cecilia Holm (1993)
Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium.Proceedings of the National Academy of Sciences of the United States of America, 90 11
M. Lafontan, M. Berlan (1993)
Fat cell adrenergic receptors and the control of white and brown fat cell function.Journal of lipid research, 34 7
Catherine Small, J. Goodacre, S. Yeaman (1989)
Hormone‐sensitive lipase is responsible for the neutral cholesterol ester hydrolase activity in macrophagesFEBS Letters, 247
J. Kim, G. Spotts, Y. Halvorsen, H. Shih, T. Ellenberger, H. Towle, B. Spiegelman (1995)
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domainMolecular and Cellular Biology, 15
K. Cook, S. Yeaman, P. Strålfors, G. Fredrikson, P. Belfrage (1982)
Direct evidence that cholesterol ester hydrolase from adrenal cortex is the same enzyme as hormone-sensitive lipase from adipose tissue.European journal of biochemistry, 125 1
(1994)
Genes V (New
G. Wen, I. Pfeiffer, T. Leeb, B. Baumgartner, D. Hui, B. Brenig (1998)
Two highly polymorphic microsatellites within the porcine secretory carrier membrane protein 1 (SCAMP1) gene.Animal genetics, 29 6
C. Sztalryd, F. Kraemer (1994)
Regulation of hormone-sensitive lipase during fasting.The American journal of physiology, 266 2 Pt 1
S. Reynisdottir, M. Eriksson, B. Angelin, P. Arner (1995)
Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia.The Journal of clinical investigation, 95 5
Z. Li, M. Sumida, A. Birchbauer, M. Schotz, K. Reue (1994)
Isolation and characterization of the gene for mouse hormone-sensitive lipase.Genomics, 24 2
(1987)
An analysis of 5
J. Ntambi, S. Buhrow, K. Kaestner, Robert Christy, Eric Sibley, T. Kelly, M. Lane (1988)
Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.The Journal of biological chemistry, 263 33
J. Schug, G. Overton (1997)
Modeling Transcription Factor Binding Sites with Gibbs Sampling and Minimum Description Length EncodingProceedings. International Conference on Intelligent Systems for Molecular Biology, 5
Jacques Grober, Henrik Laurell, Régis Blaise, Béatrice Fabry, Stéphane Schaak, Cecilia Holm, Dominique Langin (1997)
Characterization of the promoter of human adipocyte hormone-sensitive lipase.The Biochemical journal, 328 ( Pt 2)
Fook-Thean Lee, John Adams, A. Garton, S. Yeaman (1988)
Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones.Biochimica et biophysica acta, 963 2
A. Feinberg, B. Vogelstein (1984)
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.Analytical biochemistry, 137 1
J. Sambrook, E. Fritsch, T. Maniatis (2001)
Molecular Cloning: A Laboratory Manual
Valérie Large, Peter Arner, S. Reynisdottir, Jacques Grober, Vanessa Harmelen, Cecilia Holm, Dominique Langin (1998)
Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells.Journal of lipid research, 39 8
Zheng Liu, E. Simpson (1997)
Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells.Molecular endocrinology, 11 2
P. Chomczyński, N. Sacchi (1987)
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.Analytical biochemistry, 162 1
M. Nakamuta, K. Oka, J. Krushkal, Kunihisa Kobayashi, M. Yamamoto, Wen-Hsiung Li, L. Chan (1995)
Alternative mRNA Splicing and Differential Promoter Utilization Determine Tissue-specific Expression of the Apolipoprotein B mRNA-editing Protein (Apobec1) Gene in Mice.The Journal of Biological Chemistry, 270
B. Wilson, S. Deeb, G. Florant (1992)
Seasonal changes in hormone-sensitive and lipoprotein lipase mRNA concentrations in marmot white adipose tissue.The American journal of physiology, 262 2 Pt 2
K. Schoonjans, J. Peinado-Onsurbe, A. Lefebvre, R. Heyman, M. Briggs, S. Deeb, B. Staels, J. Auwerx (1996)
PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.The EMBO Journal, 15
T. Heinemeyer, E. Wingender, I. Reuter, H. Hermjakob, A. Kel, O. Kel-Margoulis, E. Ignatieva, E. Ananko, O. Podkolodnaya, F. Kolpakov, N. Podkolodny, N. Kolchanov (1998)
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPELNucleic acids research, 26 1
Rainer Rbass, C. Kalbe, J. Vanselow (1997)
Tissue-Specific Expression of the Bovine Aromatase-Encoding Gene Uses Multiple Transcriptional Start Sites and Alternative First Exons.Endocrinology, 138 7
A. Knoll, A. Stratil, M. Nebola, S. Čepica (1998)
Characterization of a polymorphism in exon 1 of the porcine hormone-sensitive lipase (LIPE) gene.Animal genetics, 29 6
Motonao Nakamura, C. Sakanaka, Y. Aoki, H. Ogasawara, T. Tsuji, H. Kodama, Takashi Matsumoto, Takao Shimizu, M. Noma (1995)
Identification of Two Isoforms of Mouse Neuropeptide Y-Y1 Receptor Generated by Alternative SplicingThe Journal of Biological Chemistry, 270
A. Feinberg, B. Vogelstein (1983)
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.Analytical biochemistry, 132 1
A. Swick, M. Lane (1992)
Identification of a transcriptional repressor down-regulated during preadipocyte differentiation.Proceedings of the National Academy of Sciences of the United States of America, 89 17
VLADIMIR STICH, ISABELLE HARANT, ISABELLE GLISEZINSKI, FRANCOIS CRAMPES, MICHEL BERLAN, MARIE KUNESOVA, VOJTECH HAINER, MICHELE DAUZATS, DANIEL RIVIÈRE, MICHEL GARRIGUES, CECILIA HOLM, MAX LAFONTAN, DOMINIQUE LANGIN (1997)
Adipose tissue lipolysis and hormone-sensitive lipase expression during very-low-calorie diet in obese female identical twins.The Journal of clinical endocrinology and metabolism, 82 3
K. Quandt, K. Frech, H. Karas, E. Wingender, Thomas Werner (1995)
MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data.Nucleic acids research, 23 23
J. Chen, M. Waterman (1992)
Two promoters in the bovine adrenodoxin gene and the role of associated, unique cAMP-responsive sequences.Biochemistry, 31 8
O. MacDougald, M. Lane (1995)
Transcriptional regulation of gene expression during adipocyte differentiation.Annual review of biochemistry, 64
M. Thompson, S. Cooper, Bryan Parry, J. Tuckey (1993)
Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients.Biochimica et biophysica acta, 1180 3
C. Sztalryd, M. Komaromy, F. Kraemer (1995)
Overexpression of hormone-sensitive lipase prevents triglyceride accumulation in adipocytes.The Journal of clinical investigation, 95 6
J. Khoo, K. Reue, D. Steinberg, M. Schotz (1993)
Expression of hormone-sensitive lipase mRNA in macrophages.Journal of lipid research, 34 11
Henrik Laurell, Henrik Laurell, Jacques Grober, Cécile Vindis, Thierry Lacombe, Michèle Dauzats, Cecilia Holm, Dominique Langin (1997)
Species-specific alternative splicing generates a catalytically inactive form of human hormone-sensitive lipase.The Biochemical journal, 328 ( Pt 1)
D. Rice, Andréa, R., Mouw, A. Bogerd, Keith, L., Parker (1991)
A shared promoter element regulates the expression of three steroidogenic enzymes.Molecular endocrinology, 5 10
Hormone-sensitive lipase (HSL) mediates triglyceride hydrolysis in adipocytes, in which its expression varies with physiological stress and is controlled posttranslationally and transcriptionally. We sequenced the mouse HSL gene for 8.2 kb upstream of the translation start codon and studied the steady-state HSL mRNA levels in mouse adipose tissue. In 50 clones derived from primer extension and PCR of mouse adipose cDNA, we found five distinct 5′ extremities that correspond to distinct exons in genomic DNA. Exon A is located ∼7 kb 5′ to the HSL translation start site. Exons B, C, and D are clustered 1.5–2 kb upstream, and the previously described exon 1 is immediately upstream and contiguous with the previously described HSL translation start site. Exon A is located ∼7 kb upstream and contains an in-frame methionine codon that could potentially generate another HSL isoform with 43 additional N-terminal residues. cDNA clones containing the newly described exons suggested that each exon has several transcription start sites but that all splice to an acceptor site located 20 nt upstream of the translation initiation codon in exon 1. HSL transcription in mouse adipose tissue originates from multiple sites in the 7-kb region between exon A and exon 1, with peaks at exon C (50–70% of HSL transcripts), exon 1 (5–30%), and exon A (∼10%). There are multiple potential transcription factor-binding elements upstream of each exon, suggesting the possibility of differential transcriptional regulation of HSL in different tissues and under various physiologic conditions.
Mammalian Genome – Springer Journals
Published: Nov 1, 2000
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.