The hemoglobin-deficit mutation is located on mouse Chromosome 19

The hemoglobin-deficit mutation is located on mouse Chromosome 19 Short Communications Incorporating Mouse Genome Mammalian Genome 9, 666–667 (1998). © Springer-Verlag New York Inc. 1998 Michael L. Bloom, Karen L. Simon-Stoos, Meghann E. Mabon National Institutes of Health, National Heart, Lung, and Blood Institute, Bldg. 10, Room 7C 118, Bethesda, Maryland 20892, USA Received: 9 January 1998 / Accepted: 6 April 1998 Hemoglobin-deficit (gene symbol hbd) occurred as a spontaneous apparent phenotypic difference was the zpp levels. Mice with a mutation in an unknown inbred agouti stock (Scheufler 1969). value of over 100 mmol/mol heme were scored as anemic. The Homozygous mice were mated to another inbred strain known as distributions of zpp, mcv, and hgb were clearly bimodal, which AB/Jena-Halle. Heterozygous mice with a black coat color and a made it possible to assign unambiguously a phenotype to each white belly spot were selected for subsequent matings. The strain mouse. The phenotyping was further confirmed by analysis of the was imported into The Jackson Laboratory in 1980, and the mu- histograms produced from the rbc counting taken with a Coulter tation was subsequently backcrossed onto the C57BL/6J back- Counter (not shown). Affected and normal mice were easily dis- ground for more than 16 generations. tinguished by the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

The hemoglobin-deficit mutation is located on mouse Chromosome 19

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Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900841
Publisher site
See Article on Publisher Site

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