Mammalian Genome 10, 768–770 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Jung Ahn, Jeffrey R. Gruen Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, 464 Congress Avenue, New Haven, Connecticut 06520-8081, USA Received: 22 December 1998 / Accepted: 26 February 1999 Histone proteins are essential for stabilizing and folding DNA in bacpac.med.buffalo.edu). Cosmid and PAC clones identified from the cell nucleus. In higher eukaryotes, four core histone proteins, the screening were grouped into several bins by dot blot hybrid- H2A, H2B, H3 and H4, form the octamer of the nucleosome, the ization and by shared STSs that were obtained from public data- smallest basic unit of chromatin structure (Stein et al. 1984). An- bases and from clone end sequences. The bins were then con- other histone, H1, interacts with linker DNA between nucleosomes nected by rescreening the libraries with clone end fragments iso- and is involved in making compact structures of chromatin. While lated by the inverse PCR method (Silver 1991). This approach all the histone genes are defined by their highly conserved coding yielded a contig of PACs and cosmids spanning 2 Mb, from sequences, expression pattern and genomic structure
Mammalian Genome – Springer Journals
Published: Jul 1, 1999
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