The genetic defect of the alkaptonuric mouse (aku)

The genetic defect of the alkaptonuric mouse (aku) Short Communications Incorporating Mouse Genome Mammalian Genome 10, 68–70 (1999). © Springer-Verlag New York Inc. 1999 1 1 1 2 1 W. Kress, S.R. Schmidt, B. Halliger-Keller, X. Montagutelli, C.R. Mu ¨ ller Department of Human Genetics, University of Wu ¨ rzburg, Biozentrum, Am Hubland, D-97074 Wu ¨ rzburg, Germany Unite´de Ge ´ne ´tique des Mammife `res, Institut Pasteur, F-75015 Paris, France Received: 29 June 1998 / Accepted: 20 August 1998 Alkaptonuria is the classical metabolic disorder in humans. At the not shown), indicating that no stable protein is being produced in dawn of modern genetics, the pathognomonic urina nigra that is the mutant. excreted by the patients led A.E. Garrod to hypothesize on a spe- Messenger RNA was prepared from livers of aku/aku and cific block in one of the (bio)chemical steps required for the deg- wild-type mice and reverse transcribed by RT-PCR. The complete radation of phenylalanine and tyrosine. The compound had been HGO-cDNA was amplified in three segments. For the 38 part of identified earlier as a derivative of tyrosine, 2,5 dihydroxyphenyl- the gene, a truncated product was obtained corresponding to a acetic acid (4 homogentisic acid, HGA). From the high rate of deletion of about http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

The genetic defect of the alkaptonuric mouse (aku)

Loading next page...
 
/lp/springer_journal/the-genetic-defect-of-the-alkaptonuric-mouse-aku-5yiGBY4dym
Publisher
Springer Journals
Copyright
Copyright © 1999 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900945
Publisher site
See Article on Publisher Site

Abstract

Short Communications Incorporating Mouse Genome Mammalian Genome 10, 68–70 (1999). © Springer-Verlag New York Inc. 1999 1 1 1 2 1 W. Kress, S.R. Schmidt, B. Halliger-Keller, X. Montagutelli, C.R. Mu ¨ ller Department of Human Genetics, University of Wu ¨ rzburg, Biozentrum, Am Hubland, D-97074 Wu ¨ rzburg, Germany Unite´de Ge ´ne ´tique des Mammife `res, Institut Pasteur, F-75015 Paris, France Received: 29 June 1998 / Accepted: 20 August 1998 Alkaptonuria is the classical metabolic disorder in humans. At the not shown), indicating that no stable protein is being produced in dawn of modern genetics, the pathognomonic urina nigra that is the mutant. excreted by the patients led A.E. Garrod to hypothesize on a spe- Messenger RNA was prepared from livers of aku/aku and cific block in one of the (bio)chemical steps required for the deg- wild-type mice and reverse transcribed by RT-PCR. The complete radation of phenylalanine and tyrosine. The compound had been HGO-cDNA was amplified in three segments. For the 38 part of identified earlier as a derivative of tyrosine, 2,5 dihydroxyphenyl- the gene, a truncated product was obtained corresponding to a acetic acid (4 homogentisic acid, HGA). From the high rate of deletion of about

Journal

Mammalian GenomeSpringer Journals

Published: Jan 1, 1999

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off