700 Mammalian Genome 8, Brief Data Reports neocortex, hippocampus, some nuclei of hypothalamus, and brain stem . On the other hand, IRKI mRNA was expressed through- out the whole brain , and IRK2 mRNA mainly in the cerebel- lum . The mouse IRK1 and IRK2 genes were mapped to the distal and central region of mouse Chr 11, respectively [10,11]. In this report, IRK3 was mapped to the distal region of mouse Chr 15. This region shares homology with human Chrs 8q and 22q (sum- marized in Fig. 1). Because Pdgfb has been placed on human 22q12.3-q13.1, the tight linkage between Kcnj4 and Pdgfb in mouse suggests that Kcnj4 will reside on 22q as well, and this result coincides with the data by Budarf and coworkers . We have compared our interspecific map of Chr 15 with a composite mouse linkage map that reports the map location of many uncloned mouse mutations (provided from Mouse Genome Database, a com- puterized database maintained at The Jackson Laboratory, Bar Harbor, ME). Although Kcnj4 mapped to a region of the composite map that contains mouse mutation med (motor end-plate disease [ 12]), med mutation has been identified on the novel voltage-gated sodium
Mammalian Genome – Springer Journals
Published: Mar 31, 2009
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