The gene encoding the Fos-related antigen 2 (Fosl2) maps to mouse chromosome 5

The gene encoding the Fos-related antigen 2 (Fosl2) maps to mouse chromosome 5 Mammalian Genome 8, Brief Data Reports 223 from the Minist~re de l'Enseignement Sup6rieur et de la Recherche The gene encoding the Fos-related antigen 2 (MESR). This work has been supported by grants from the Association (Fosl2) maps to mouse Chromosome 5 Franqaise contre les Myopathies (AFM) and Groupernent de Recherches et d'Etudes sur les G6nomes (GREG). C. Poirier, l A. Lalouette, l V.C. Foletta, 2 D.R. Cohen, 2 References Jean-Louis Gu~net 1 1. Foletta VC, Sonobe MH, Suzuki T, Endo T, Iba H., Cohen DR (1994) Oncogene 9, 3305-3311 1Unit6 de Grnrtique des Mammif~res, 25 rue du Docteur Roux, Institut 2. Montagutelli X, Lalouette A, Coud6 M, Kamoun P, Forest M, Gurnet Pasteur, 75724 Paris cedex 15, France J-L (1994) Genomics 19, 9-11 2Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, 3. Matsu M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (1990) Canberra ACT, Australia Oncogene 5, 249-255 4. Nishina H, Sato H, Suzuki T, Sato M, Iba H (1990) Proc Natl Acad Sci Received: 13 February 1996 / Accepted: 18 March 1996 USA 87 3619-3623 5. d'Eustachio P (1994) Mamm Genome 5, S181-S195 6. Lazo PS, Doffman K, Noguchi T, Mattri M-G, Bravo R (1992) Nucleic Species: Mouse Acids Res 20, 343-350 Locus name: Fos like antigen 2 [1]. 7. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P (1988) Cell Locus symbol: Fosl2 55, 917-924 Map position: cen-ll6-2.5 (0.3-8.7)-Fos12-15 (8.0-24.7)-D5Nds2 8. Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1993) Ge- for a 95% confidence interval. nomics 18, 165 Method of mapping: 80 interspecific backcross progeny: (AKUxPWK) x AKU [2]. Allele detection: Fosl2 gene was mapped using a polymorphic microsatellite localized in the promoter region of the gene [1]. The trefoil gene maps to mouse The following pair of primers allows amplification of this micro- satellite: Chromosome 17 5' GCAAGTTAATFGGAAGGCCA 3' M. Burmeister, G.E. Meyer and Mental Health Research Institute, Department of Psychiatry and Human Genetics, University of Michigan, 205 Zina Pitcher Place, 5' TTTTCACTCGGAGCCTGG 3' Ann Arbor Michigan 48109-0720, USA The PCR product is 164bp long with AKU genomic DNA as template Received: 15 August 1996 / Accepted: 24 October 1996 and 160bp long with PWK genomic DNA. Previously identified homologs: Human [3] and chicken [4]. Discussion: To date four genes encoding proteins that are antigenically Species: Mouse related to the FOS protein have been identified: Locus name: Intestinal trefoil factor 3 Locus symbol: Tff3 9 Fos itself (mouse Chr 12) [5] 9 Fosb (mouse Chr 7) [6] Map position: Chromosome (Chr) 17:Tsc2 (10.3)-1.1 + 1.1 cM- 9 Fosll and Fosl2 D17Hun6 (14.0)-5.1 + 2.5 cM-D17Hun7, 8, 9, 10, 11, 12, 13 (17.0)/Tff3-1.1 + 1.1 cM-Msk (18.18). The numbers in parenthe- All these proteins are able to interact with members of the JUN family to ses refer to the location of all markers except Tff3 according to the form the AP1 complex [7]. latest Chr 17 consensus map [1]. We have mapped Fosl2 to mouse Chr 5 in a region sharing Method of mapping: Determined from analysis of the publicly homology of synteny either with human 7p or 4p regions. available Mus spretus/C57BL/6J backcross mapping panel BSS, FOSL1, the human homolog of Fosll, has been assigned to consisting of 94 animals [2]. The scorings are available on the human chromosome 1 lq13 in a region syntenic with mouse Chr 19 WWW site ( [8]. This means that Fos and Fos-related gene family members are BSS.html). not clustered in the mouse genome. Molecular reagents: The insert of probe ITF3 (coding for nucleo- tide position 1-232, containing most of the coding region [3]) was Acknowledgements: C.P. is recipient of a fellowship from the Association amplified by PCR with Sp6 and T7 primers from the cloned plas- Franqaise contre les Myopathies (AFM). A.L. is recipient of a fellowship mid sample provided by Professor Yukifumi Nawa. Allele detection: Two polymorphisms between Mus spretus (1.4 and =9 kb) and C57B 1/6J (1.8 and =8.5 kb) DNA were detected by hybridization to Southern blots of BgllI-digested DNA. Both poly- Correspondence to: J. Louis Gurnet morphisms co-segregated. Previously identified homologs: The human TFF3 gene has pre- viously been mapped within 250 kb of two other trefoil genes, BCE-I and SML1, on 21q22.3 [4]. Discussion: Trisomy of human Chr 21 causes Down syndrome. In Markers Haplotypes order to develop mouse models for this disorder, it is important to know which mouse chromosomes are homologous to human Chr " DIDIDI 21. While most of human Chr 21 is homologous to mouse Chr 16, Fosl2 DIII-IFll and a mouse trisomic for this part of mouse Chr 16 has recently Fig. 1. Haplotype analysis of 80 FIlIFIlF1 mice. Filled boxes: heterozygous, Numbers 36 30 1 l 6 6 open boxes: homozygous. Correspondence to: M. Burmeister Mammalian Genome Springer Journals

The gene encoding the Fos-related antigen 2 (Fosl2) maps to mouse chromosome 5

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Life Sciences; Cell Biology; Anatomy; Zoology
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