The gene encoding rat 3-phosphoglycerate dehydrogenase

The gene encoding rat 3-phosphoglycerate dehydrogenase Short Communications Incorporating Mouse Genome Mammalian Genome 11, 1034–1036 (2000). © Springer-Verlag New York Inc. 2000 DOI: 10.1007/s003350010189 1 1 2 1 Mariette Robbi, Younes Achouri, Claude Szpirer, Emile Van Schaftingen Laboratoire de Chimie Physiologique, Christian de Duve Institute of Cellular Pathology and Universite ´ Catholique de Louvain, Avenue Hippocrate 75, B-1200 Brussels Belgium Laboratoire de Biologie du De ´veloppement, I.B.M.M., Universite ´ Libre de Bruxelles, B-6041 Gosselies, Belgium Received: 17 March 2000 / Accepted: 23 June 2000 The first step of L-serine synthesis is catalyzed by 3-phosphoglyc- Except for a » 250-bp, highly repetitive region in the second half of st erate dehydrogenase (PHGDH), a ubiquitous enzyme in prokary- intron 5, the whole gene and 5 kbp upstream of the 1 exon were otes and eukaryotes. The sequence encoding this enzyme, now completely sequenced on both strands (» 20 kbp) or on one strand known for many species including rat (Achouri et al. 1997) and with large overlaps between successive starting points (» 14 kbp). human (Cho et al. 2000), shows that it belongs to the family of Figure 1 shows the structure of the gene. It contains 13 exons, D-hydroxyacid dehydrogenases (Vinals et al. 1993), which also Mammalian Genome Springer Journals

The gene encoding rat 3-phosphoglycerate dehydrogenase

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Copyright © 2000 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
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