The gene encoding β-galactoside α2,6-sialyltransferase maps to mouse Chromosome 16

The gene encoding β-galactoside α2,6-sialyltransferase maps to mouse Chromosome 16 Mammalian Genome 8, Brief Data Reports 619 7. Gelb BD, Cooper E, Shevell M, Desnick RJ (1995) Am J Med Genet 58, The region on mouse Chr 17 to which Mdfi was mapped in- 200-205 cludes several genes that also map to human Chr 6p21. Based on the synteny between mouse and human chromosomes in this re- 8. Mundlos S, Mulliken JB, Abrahamson DL, Warman ML, Knoll JHM, Olsen BR (1995) Hum Mol Genet 4, 71-75 gion, these data predict that the human MDFI gene will be mapped to Chr 6p21 (see Fig. 1B). Human MDFI cDNA was isolated from 9. Sillence DO, Ritchie HE, Selby PB (1987) Am J Med Genet 27, 75-85 a human fetal brain cDNA library in Lambda ZapII (Stratagene) following high-stringency hybridization with a probe generated by RT-PCR from a human bone preparation with primers specific for mouse Mdfi. The isolated cDNA inserts contained an open reading The gene encoding 13-galactoside frame of 246 amino acids with 80% identity to mouse I-mfa, with c~2,6-sialyltransferase maps to mouse 98% identity and 100% similarity in the cysteine-rich MyoD- Chromosome 16 interactional domain required for its myogenic repressor function (Gen Bank Accession No. for human MDFI is Mammalian Genome Springer Journals

The gene encoding β-galactoside α2,6-sialyltransferase maps to mouse Chromosome 16

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Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
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