The gas-dynamic effects of a hemisphere-cylinder obstacle in a shock-tube driver

The gas-dynamic effects of a hemisphere-cylinder obstacle in a shock-tube driver One form of gene and drug delivery can be achieved by accelerating micro-particles to a sufficient momentum to penetrate the outer layer of the skin, and target the tissue below. In hand-held clinical systems, the particles are accelerated in the transonic flow developed within a miniature shock-tube. These devices require a gas reservoir to be positioned co-axially inside the driver. This paper reports the examination of a nominally constant-area shock-tube containing a co-axial obstacle in the driver section (Case 2). As a control, the flow-field in a prismatic shock-tube of the same cross-sectional area, with the same initial conditions is also studied (Case 1). Static and Pitot pressures measured in each of the above cases are compared to one-dimensional theory and numerical computations. Significant deviations between Cases 1 & 2 are observed in the driver, but not in the driven section. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experiments in Fluids Springer Journals

The gas-dynamic effects of a hemisphere-cylinder obstacle in a shock-tube driver

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Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag
Subject
Engineering; Engineering Fluid Dynamics; Fluid- and Aerodynamics; Engineering Thermodynamics, Heat and Mass Transfer
ISSN
0723-4864
eISSN
1432-1114
D.O.I.
10.1007/s00348-004-0896-x
Publisher site
See Article on Publisher Site

Abstract

One form of gene and drug delivery can be achieved by accelerating micro-particles to a sufficient momentum to penetrate the outer layer of the skin, and target the tissue below. In hand-held clinical systems, the particles are accelerated in the transonic flow developed within a miniature shock-tube. These devices require a gas reservoir to be positioned co-axially inside the driver. This paper reports the examination of a nominally constant-area shock-tube containing a co-axial obstacle in the driver section (Case 2). As a control, the flow-field in a prismatic shock-tube of the same cross-sectional area, with the same initial conditions is also studied (Case 1). Static and Pitot pressures measured in each of the above cases are compared to one-dimensional theory and numerical computations. Significant deviations between Cases 1 & 2 are observed in the driver, but not in the driven section.

Journal

Experiments in FluidsSpringer Journals

Published: Jan 29, 2005

References

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