The epigenetic mechanism of the effect of mildly deleterious mutations on the viability of the progeny and their correction in meiosis

The epigenetic mechanism of the effect of mildly deleterious mutations on the viability of the... Data supporting the hypothesis about the epigenetic nature of deleterious mutations leading to the death of a part of the progeny are presented. It is assumed that during the life cycle “mutant” variants of formation of structural-functional loop domains occur in chromosomes that normally are corrected during meiosis. An abnormal loop changes the activity of many tens of genes, both increasing (+) and decresing (−) it, which affects the viability of homozygotes and to a lesser extent the viability of heterozygotes. Hybrids with chromosomes containing independently accumulated deleterious mutations partly restore their viability due to the complementary interactions of + and − genes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

The epigenetic mechanism of the effect of mildly deleterious mutations on the viability of the progeny and their correction in meiosis

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2010 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795410100169
Publisher site
See Article on Publisher Site

Abstract

Data supporting the hypothesis about the epigenetic nature of deleterious mutations leading to the death of a part of the progeny are presented. It is assumed that during the life cycle “mutant” variants of formation of structural-functional loop domains occur in chromosomes that normally are corrected during meiosis. An abnormal loop changes the activity of many tens of genes, both increasing (+) and decresing (−) it, which affects the viability of homozygotes and to a lesser extent the viability of heterozygotes. Hybrids with chromosomes containing independently accumulated deleterious mutations partly restore their viability due to the complementary interactions of + and − genes.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 13, 2010

References

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