Although several studies have evaluated the effect of synbiotic intake on metabolic profiles in patients with diabetes, findings are inconsistent. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the evidence on the effect of synbiotic intake on metabolic profiles in patients with diabetes. The PubMed, EMBASE, Web of Science, and Cochrane Library databases were systematically searched. All RCTs published up to 12 November 2016 were included. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q test and with I 2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95% confidence interval (CI). A total of seven randomized controlled trials were included. Synbiotic consumption significantly changed glucose metabolism, including fasting plasma glucose (FPG) (SMD = −0.29; 95% CI, −0.47, −0.10), insulin concentrations (SMD = −0.84; 95% CI, −1.61, −0.06), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD = −0.80; 95% CI, −1.58, −0.03), homeostatic model assessment-B cell function (HOMA-B) (SMD = −0.36; 95% CI, −0.71, −0.01), quantitative insulin sensitivity check index (QUICKI) (SMD = 0.46; 95% CI, 0.09, 0.82), and significantly improved lipid profiles, such as triglycerides (SMD = −0.36; 95% CI, −0.55, −0.17), very low density lipoprotein-cholesterol (SMD = −0.31; 95% CI, −0.55, −0.08), and total cholesterol (SMD = −0.32; 95% CI, −0.67, −0.03), but had no effect on low density lipoprotein-cholesterol (SMD = −0.07; 95% CI, −0.58, 0.43) and high density lipoprotein-cholesterol concentrations (SMD = −0.25; 95% CI, −0.81, 0.31). Synbiotic may result in an improvement in FPG, insulin, HOMA-IR, HOMA-B, QUICKI, triglycerides, and total cholesterol.
Probiotics and Antimicrobial Proteins – Springer Journals
Published: Jul 4, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera