The effects of acellular dermal graft (AlloDerm®) use on capsular formation due to silicone were studied. Twenty New Zealand rabbits, weighing 2,500–3,000 g, were used in the study. Textured silicone membrane fragments, 2 × 1 cm in size and wrapped with AlloDerm®, were placed subcutaneously in right thoracodorsal regions in the experiment group, composed of ten subjects. In the control group of ten subjects, the naked fragments were inserted into the same locations in left thoracodorsal regions. After a period of 12 weeks, implants, fascia, subcutaneous tissue, and skin were removed en bloc from both groups and examined macroscopically and histopathologically in terms of adhesions to surrounding tissues, capsule thickness, structural properties, the amount of fibroblasts and myofibroblasts, histiocytes, polymorphonuclear leucocytes, and lymphocytes. Statistical analysis of the histopathologic findings was done using Student’s T test. The capsule in the experiment group was found to be thinner and less cellular; this related to fibroblasts and myofibroblasts in comparison to the control group.Preliminary findings in utilizing acellular dermal allograft (AlloDerm®) as a wrap around the implant have shown positive results in minimizing the capsular formation and the possibility of further capsular contraction.
European Journal of Plastic Surgery – Springer Journals
Published: Aug 1, 2008
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