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/lp/springer_journal/the-effect-of-vitamin-b12-and-folic-acid-supplementation-on-routine-A7wnNrT0HA
- Publisher
- Springer Journals
- Copyright
- Copyright © 2018 by Macmillan Publishers Limited, part of Springer Nature
- Subject
- Medicine & Public Health; Medicine/Public Health, general; Public Health; Epidemiology; Internal Medicine; Clinical Nutrition; Metabolic Diseases
- ISSN
- 0954-3007
- eISSN
- 1476-5640
- DOI
- 10.1038/s41430-018-0118-x
- Publisher site
- See Article on Publisher Site
Abstract
Background/objectives Low vitamin B12 and folate levels in community-dwelling older people are usually corrected with supplements. However, the effect of this supplementation on haematological parameters in older persons is not known. Therefore, we executed a systematic review and individual participant data meta-analysis of randomised placebo-controlled trials (RCTs). Subjects/methods We performed a systematic search in PubMed, EMBASE, Web of Science, Cochrane and CENTRAL for RCTs published between January 1950 and April 2016, where community-dwelling elderly (60+ years) who were treated with vitamin B12 or folic acid or placebo. The presence of anaemia was not required. We analysed the data on haemato- logical parameters with a two-stage IPD meta-analysis. Results We found 494 full papers covering 14 studies. Data were shared by the authors of four RCTs comparing vitamin B12 with placebo (n = 343) and of three RCTs comparing folic acid with placebo (n = 929). We found no effect of vitamin B12 supplementation on haemoglobin (change 0.00 g/dL, 95% CI: −0.19;0.18), and no effect of folic acid supplementation (change −0.09 g/dL, 95% CI: −0.19;0.01). The effects of supplementation on other haematological parameters were similar. The effects did not differ by sex or by age group. Also, no effect was
Journal
European Journal of Clinical Nutrition – Springer Journals
Published: Mar 8, 2018
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