The effect of the Primary Structure of DNA on Induction of Mutations by Alkylating Agents

The effect of the Primary Structure of DNA on Induction of Mutations by Alkylating Agents Analysis and comparison of mutation spectra is one of the major tasks of molecular biology, since mutation spectra often reveal important properties of various mutagens and proteins involved in the repair/replication systems. Mutability is known to vary significantly along the nucleotide sequence. Mutations are abundant at certain positions (mutation hotspots). In this work, we applied regression analysis based on the basic logic patterns to understand the role of the nucleotide sequence context in mutation induction. The spectra of mutations induced by various alkylating agents were studied. The nucleotide bases at positions –2, –1, +1 and +2 were shown to have the most significant effect in G : C → A : T replacements. Russian Journal of Genetics Springer Journals

The effect of the Primary Structure of DNA on Induction of Mutations by Alkylating Agents

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Kluwer Academic Publishers-Plenum Publishers
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Biomedicine; Human Genetics
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