The purpose of this study was to evaluate the effect of the atelocollagen matrix and basic fibroblast growth factor (bFGF) on bone regeneration in a bone defect of the calvaria. The subjects were 10-week-old male Wister rats weighing 350 g. Two kinds of atelocollagen matrices, which were either strongly cross-linked or weakly cross-linked, were placed in defects created in the rat cranium. Two doses of bFGF, either 30 μg or 50 μg, were injected into the weakly cross-linked atelocollagen matrix. Both the bone mineral content in the defects and the area of bone regeneration in the median sections of the defects were measured 2, 4, and 8 weeks after surgical treatment. Our findings suggested that the weakly cross-linked atelocollagen matrix tends to demonstrate a scaffold of bone regeneration, and an appropriate dosage of bFGF may inhibit bone absorption to maintain the volume of the regenerated bone.
European Journal of Plastic Surgery – Springer Journals
Published: Apr 1, 2006
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