The effect of selective genotyping on QTL mapping accuracy

The effect of selective genotyping on QTL mapping accuracy Mammalian Genome 8, 67-68 (1997). 9 Springer-Verlag New York Inc. 1997 A. Darvasi Grnrtique Neurogrnrtique et Comportement, URA 1294 CNRS, UFR Biomrdicale, Universit6 Rene Descartes (Paris V), 45 rue des Saints-P~res, 75270 Paris Cedex 06, France Received: 14 July 1996 / Accepted: 21 August 1996 The detection of quantitative trait loci (QTL) requires large sample combination. Heron, CI is referred to as the length of the 95% confidence interval. sizes to attain reasonable power (Soller et al. 1976). For reduction of the number of individuals needed to be genotyped in marker- The equivalence of various experimental designs (BC, F2, half- sibs) when using selective genotyping has also been presented QTL linkage experiments, a procedure termed "selective genotyp- (Darvasi and Soller 1992). Consequently, the present model serves ing" has been proposed for experimental species (Darvasi and as a close approximation to a wide range of actual experimental Soller 1992; Lander and Botstein 1989; Lebowitz et al. 1987) and conditions. has been adapted for humans as well (Risch and Zhang 1995). Previous studies have shown that CI is mainly a function of With selective genotyping, only individuals from the high and low sample size, N, and gene effect, d (Darvasi et http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

The effect of selective genotyping on QTL mapping accuracy

Loading next page...
 
/lp/springer_journal/the-effect-of-selective-genotyping-on-qtl-mapping-accuracy-CNclyoSo8e
Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900353
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial