Mammalian Genome 8, 67-68 (1997). 9 Springer-Verlag New York Inc. 1997 A. Darvasi Grnrtique Neurogrnrtique et Comportement, URA 1294 CNRS, UFR Biomrdicale, Universit6 Rene Descartes (Paris V), 45 rue des Saints-P~res, 75270 Paris Cedex 06, France Received: 14 July 1996 / Accepted: 21 August 1996 The detection of quantitative trait loci (QTL) requires large sample combination. Heron, CI is referred to as the length of the 95% confidence interval. sizes to attain reasonable power (Soller et al. 1976). For reduction of the number of individuals needed to be genotyped in marker- The equivalence of various experimental designs (BC, F2, half- sibs) when using selective genotyping has also been presented QTL linkage experiments, a procedure termed "selective genotyp- (Darvasi and Soller 1992). Consequently, the present model serves ing" has been proposed for experimental species (Darvasi and as a close approximation to a wide range of actual experimental Soller 1992; Lander and Botstein 1989; Lebowitz et al. 1987) and conditions. has been adapted for humans as well (Risch and Zhang 1995). Previous studies have shown that CI is mainly a function of With selective genotyping, only individuals from the high and low sample size, N, and gene effect, d (Darvasi et
Mammalian Genome – Springer Journals
Published: Mar 23, 2009
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