The effect of pentoxifylline on the healing of full-thickness skin defects of diabetic and normal rats

The effect of pentoxifylline on the healing of full-thickness skin defects of diabetic and normal... In this paper, the effects of systemic pentoxifylline administration on normal and diabetic wound healing are studied. Twenty-four normoglycemic and 24 diabetic rats were compared, exploring the healing of standardized (15×15 mm) full-thickness wounds by secondary intention. Twelve rats of both groups received intraperitoneal pentoxifylline 10 mg/kg per day. The strength of the healed tissues was evaluated by straining tests, the healing time of each wound was recorded, and the healed tissues were examined histologically. In the diabetic group, the only significant difference between the rats receiving pentoxifylline and the others was the shortened healing time. Pentoxifylline significantly reduced the time needed for complete epithelization and also increased the tensile strength significantly in normoglycemic rats. As expected, significant differences were recorded between the normoglycemic and diabetic rats regarding healing time and scar tissue strength. In conclusion, systemic pentoxifylline administration may be helpful in shortening the healing time of full-thickness wounds both in diabetic and normoglycemic patients, and it can increase the tensile strength of the healed wound in normoglycemic organisms. European Journal of Plastic Surgery Springer Journals

The effect of pentoxifylline on the healing of full-thickness skin defects of diabetic and normal rats

Loading next page...
Copyright © 2002 by Springer-Verlag
Medicine & Public Health; Plastic Surgery
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial