Eur J Plast Surg (2001) 24:228–229 DOI 10.1007/s002380100269 INVITED COMMENTAR Y Ziv M. Peled · Michael T. Longaker The effect of hyaluronan on adult and fetal fibroblast proliferation and collagen synthesis: an in vitro study Published online: 7 August 2001 © Springer-Verlag 2001 In their work entitled “The Effect of Hyaluronan On ically, the time to confluence for the treated adult fibro- Adult and Fetal Fibroblast Proliferation and Collagen blasts decreased as compared to the untreated adult fi- Synthesis: An In Vitro Study,” Deveci et al. have investi- broblasts and actually approximated that of treated and gated an important extracellular matrix (ECM) compo- untreated fetal cells. Transmission electron microscopic nent of the fetal wound, namely, hyaluronic acid (HA). analysis showed that untreated adult fibroblasts had a The interesting component of this study is the perspec- spindle-shaped morphology with fewer granular endo- tive that the authors have taken with respect to this mole- plasmic reticulum (ER) and Golgi apparatuses. This cule. As they correctly point out in their discussion, there group also demonstrated large collagen fibers. In con- has been some debate as to whether the prolonged pres- trast, the treated adult fibroblasts as well as the treated ence of
European Journal of Plastic Surgery – Springer Journals
Published: Sep 1, 2001
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